Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

BACKGROUND: Granulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GCT and it is likely to contribute to their dev...

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Detalles Bibliográficos
Autores principales: Fleming, Nicholas I., Knower, Kevin C., Lazarus, Kyren A., Fuller, Peter J., Simpson, Evan R., Clyne, Colin D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004790/
https://www.ncbi.nlm.nih.gov/pubmed/21188138
http://dx.doi.org/10.1371/journal.pone.0014389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004790/
https://www.ncbi.nlm.nih.gov/pubmed/21188138
http://dx.doi.org/10.1371/journal.pone.0014389

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