Cargando…

Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

BACKGROUND: Granulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GCT and it is likely to contribute to their dev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fleming, Nicholas I., Knower, Kevin C., Lazarus, Kyren A., Fuller, Peter J., Simpson, Evan R., Clyne, Colin D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004790/ https://www.ncbi.nlm.nih.gov/pubmed/21188138 http://dx.doi.org/10.1371/journal.pone.0014389

Ejemplares similares

FOXO1 mitigates the SMAD3/FOXL2(C134W) transcriptomic effect in a model of human adult granulosa cell tumor
por: Secchi, Christian, et al.
Publicado: (2021)

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target
por: Pierini, Stefano, et al.
Publicado: (2020)

Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
por: Benayoun, Bérénice A., et al.
Publicado: (2010)

The Orphan Nuclear Receptor LRH-1 and ERα Activate GREB1 Expression to Induce Breast Cancer Cell Proliferation
por: Chand, Ashwini L., et al.
Publicado: (2012)

Aromatase expression is increased in BRCA1 mutation carriers
por: Chand, Ashwini L, et al.
Publicado: (2009)

The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells
por: Georges, Adrien, et al.
Publicado: (2014)

The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours
por: Rosario, Roseanne, et al.
Publicado: (2012)

Overexpression of Wild-Type but Not C134W Mutant FOXL2 Enhances GnRH-Induced Cell Apoptosis by Increasing GnRH Receptor Expression in Human Granulosa Cell Tumors
por: Cheng, Jung-Chien, et al.
Publicado: (2013)

Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
por: Van Sinderen, Michelle L., et al.
Publicado: (2014)

FOXO1 Mitigation of FOXL2C143W/SMAD3 Transcriptomic Landscape in a Model of Granulosa Cell Tumor
por: Secchi, Christian, et al.
Publicado: (2021)

Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation
por: Wang, Wen-Chung, et al.
Publicado: (2014)

Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis
por: Rosen, Emily R., et al.
Publicado: (2018)

Adult‐type granulosa cell tumor of the ovary: a FOXL2‐centric disease
por: Pilsworth, Jessica A, et al.
Publicado: (2021)

Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci
por: Fischer, Anne Kristin, et al.
Publicado: (2022)

Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter
por: Escudero, Jean M, et al.
Publicado: (2010)

Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells
por: Lin, Lina, et al.
Publicado: (2022)

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary
por: Kraus, Francois, et al.
Publicado: (2020)

FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells
por: Anttonen, Mikko, et al.
Publicado: (2014)

Expression of FOXL2 and RSPO1 in Hen Ovarian Follicles and Implication of Exogenous Leptin in Modulating Their mRNA Expression in In Vitro Cultured Granulosa Cells
por: Niu, Weihe, et al.
Publicado: (2019)

FOXO1 Negates the Cooperative Action of FOXL2(C134W) and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3
por: Belli, Martina, et al.
Publicado: (2019)

Retreatment with aromatase inhibitor therapy in the management of granulosa cell tumor
por: Schwartz, Melissa, et al.
Publicado: (2015)

Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells
por: Rooda, Ilmatar, et al.
Publicado: (2020)

FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells
por: Jin, Hanyong, et al.
Publicado: (2016)

Oleic acid induces down-regulation of the granulosa cell identity marker FOXL2, and up-regulation of the Sertoli cell marker SOX9 in bovine granulosa cells
por: Yenuganti, Vengala Rao, et al.
Publicado: (2017)

Maximal Expression of Foxl2 in Pituitary Gonadotropes Requires Ovarian Hormones
por: Herndon, Maria K., et al.
Publicado: (2015)

Rosiglitazone and Pioglitazone Alter Aromatase Kinetic Properties in Human Granulosa Cells
por: Araki, Takako, et al.
Publicado: (2011)

Estrogen disorders: Interpreting the abnormal regulation of aromatase in granulosa cells (Review)
por: Liu, Ting, et al.
Publicado: (2021)

New small‐molecule compound Hu‐17 inhibits estrogen biosynthesis by aromatase in human ovarian granulosa cancer cells
por: Xi, Yang, et al.
Publicado: (2020)

Identification of SF-1 and FOXL2 and Their Effect on Activating P450 Aromatase Transcription via Specific Binding to the Promoter Motifs in Sex Reversing Cheilinus undulatus
por: Ji, Xinxin, et al.
Publicado: (2022)

Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles
por: Qin, Ning, et al.
Publicado: (2015)

Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation
por: Yanagida, Satoshi, et al.
Publicado: (2017)

Melatonin stimulates aromatase expression and estradiol production in human granulosa-lutein cells: relevance for high serum estradiol levels in patients with ovarian hyperstimulation syndrome
por: Cheng, Jung-Chien, et al.
Publicado: (2020)

Novel FOXL2 mutations cause blepharophimosis‐ptosis‐epicanthus inversus syndrome with premature ovarian insufficiency
por: Yang, Xiao‐Wen, et al.
Publicado: (2018)

Ovarian Reserve and ART Outcomes in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Patients With FOXL2 Mutations
por: Meng, Tingting, et al.
Publicado: (2022)

Reelin and aromatase cooperate in ovarian follicle development
por: Meseke, Maurice, et al.
Publicado: (2018)

Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells
por: Jiajie, Tu, et al.
Publicado: (2017)

Inhibition of the Aromatase Enzyme by Exemestane Cysteine Conjugates
por: Teslenko, Irina, et al.
Publicado: (2022)

R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation
por: Kocer, Ayhan, et al.
Publicado: (2008)

Differential Apoptotic and Proliferative Activities of Wild-type FOXL2 and Blepharophimosis-ptosis-epicanthus Inversus Syndrome (BPES)-associated Mutant FOXL2 Proteins
por: KIM, Jae-Hong, et al.
Publicado: (2013)

OR19-05 Human Induced Pluripotent Stem Cell-derived Granulosa-like Cells From Ligand-based Differentiation Express FOXL2 After Inhibition Of DKK1
por: Kubo, Hana, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nijcdqiepduik1t5ek99lcmdit