Cargando…

The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder

BACKGROUND: Cognitive behavioral therapy (CBT) represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of experimentally acquired fe...

Descripción completa

Detalles Bibliográficos
Autores principales: Lonsdorf, Tina B, Rück, Christian, Bergström, Jan, Andersson, Gerhard, Öhman, Arne, Lindefors, Nils, Schalling, Martin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004861/
https://www.ncbi.nlm.nih.gov/pubmed/21110842
http://dx.doi.org/10.1186/1471-244X-10-99
_version_ 1782194041211846656
author Lonsdorf, Tina B
Rück, Christian
Bergström, Jan
Andersson, Gerhard
Öhman, Arne
Lindefors, Nils
Schalling, Martin
author_facet Lonsdorf, Tina B
Rück, Christian
Bergström, Jan
Andersson, Gerhard
Öhman, Arne
Lindefors, Nils
Schalling, Martin
author_sort Lonsdorf, Tina B
collection PubMed
description BACKGROUND: Cognitive behavioral therapy (CBT) represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of experimentally acquired fear responses. We have recently demonstrated that the ability to extinguish learned fear responses is associated with a functional genetic polymorphism (COMTval158met) in the COMT gene and this study was aimed at transferring the experimental results on the COMTval158met polymorphism on extinction into a clinical setting. METHODS: We tested a possible effect of the COMTval158met polymorphism on the efficacy of CBT, in particular exposure-based treatment modules, in a sample of 69 panic disorder patients. RESULTS: We present evidence that panic patients with the COMTval158met met/met genotype may profit less from (exposure-based) CBT treatment methods as compared to patients carrying at least one val-allele. No association was found with the 5-HTTLPR/rs25531 genotypes which is presented as additional material. CONCLUSIONS: We were thus able to transfer findings on the effect of the COMTval158met polymorphism from an experimental extinction study obtained using healthy subjects to a clinical setting. Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met/met genotype. Limitations of the study as well as possible clinical implications are discussed. TRIAL REGISTRATION: Clinical Trial Registry name: Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder (IP2). Registration Identification number: NCT00845260, http://www.clinicaltrials.gov/ct2/show/NCT00845260
format Text
id pubmed-3004861
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30048612010-12-21 The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder Lonsdorf, Tina B Rück, Christian Bergström, Jan Andersson, Gerhard Öhman, Arne Lindefors, Nils Schalling, Martin BMC Psychiatry Research Article BACKGROUND: Cognitive behavioral therapy (CBT) represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of experimentally acquired fear responses. We have recently demonstrated that the ability to extinguish learned fear responses is associated with a functional genetic polymorphism (COMTval158met) in the COMT gene and this study was aimed at transferring the experimental results on the COMTval158met polymorphism on extinction into a clinical setting. METHODS: We tested a possible effect of the COMTval158met polymorphism on the efficacy of CBT, in particular exposure-based treatment modules, in a sample of 69 panic disorder patients. RESULTS: We present evidence that panic patients with the COMTval158met met/met genotype may profit less from (exposure-based) CBT treatment methods as compared to patients carrying at least one val-allele. No association was found with the 5-HTTLPR/rs25531 genotypes which is presented as additional material. CONCLUSIONS: We were thus able to transfer findings on the effect of the COMTval158met polymorphism from an experimental extinction study obtained using healthy subjects to a clinical setting. Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met/met genotype. Limitations of the study as well as possible clinical implications are discussed. TRIAL REGISTRATION: Clinical Trial Registry name: Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder (IP2). Registration Identification number: NCT00845260, http://www.clinicaltrials.gov/ct2/show/NCT00845260 BioMed Central 2010-11-26 /pmc/articles/PMC3004861/ /pubmed/21110842 http://dx.doi.org/10.1186/1471-244X-10-99 Text en Copyright ©2010 Lonsdorf et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lonsdorf, Tina B
Rück, Christian
Bergström, Jan
Andersson, Gerhard
Öhman, Arne
Lindefors, Nils
Schalling, Martin
The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
title The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
title_full The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
title_fullStr The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
title_full_unstemmed The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
title_short The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
title_sort comtval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004861/
https://www.ncbi.nlm.nih.gov/pubmed/21110842
http://dx.doi.org/10.1186/1471-244X-10-99
work_keys_str_mv AT lonsdorftinab thecomtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT ruckchristian thecomtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT bergstromjan thecomtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT anderssongerhard thecomtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT ohmanarne thecomtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT lindeforsnils thecomtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT schallingmartin thecomtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT lonsdorftinab comtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT ruckchristian comtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT bergstromjan comtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT anderssongerhard comtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT ohmanarne comtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT lindeforsnils comtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder
AT schallingmartin comtval158metpolymorphismisassociatedwithsymptomreliefduringexposurebasedcognitivebehavioraltreatmentinpanicdisorder