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Monitoring spindle orientation: Spindle position checkpoint in charge
Every cell division in budding yeast is inherently asymmetric and counts on the correct positioning of the mitotic spindle along the mother-daughter polarity axis for faithful chromosome segregation. A surveillance mechanism named the spindle position checkpoint (SPOC), monitors the orientation of t...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004881/ https://www.ncbi.nlm.nih.gov/pubmed/21143992 http://dx.doi.org/10.1186/1747-1028-5-28 |
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author | Caydasi, Ayse K Ibrahim, Bashar Pereira, Gislene |
author_facet | Caydasi, Ayse K Ibrahim, Bashar Pereira, Gislene |
author_sort | Caydasi, Ayse K |
collection | PubMed |
description | Every cell division in budding yeast is inherently asymmetric and counts on the correct positioning of the mitotic spindle along the mother-daughter polarity axis for faithful chromosome segregation. A surveillance mechanism named the spindle position checkpoint (SPOC), monitors the orientation of the mitotic spindle and prevents cells from exiting mitosis when the spindle fails to align along the mother-daughter axis. SPOC is essential for maintenance of ploidy in budding yeast and similar mechanisms might exist in higher eukaryotes to ensure faithful asymmetric cell division. Here, we review the current model of SPOC activation and highlight the importance of protein localization and phosphorylation for SPOC function. |
format | Text |
id | pubmed-3004881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30048812010-12-21 Monitoring spindle orientation: Spindle position checkpoint in charge Caydasi, Ayse K Ibrahim, Bashar Pereira, Gislene Cell Div Review Every cell division in budding yeast is inherently asymmetric and counts on the correct positioning of the mitotic spindle along the mother-daughter polarity axis for faithful chromosome segregation. A surveillance mechanism named the spindle position checkpoint (SPOC), monitors the orientation of the mitotic spindle and prevents cells from exiting mitosis when the spindle fails to align along the mother-daughter axis. SPOC is essential for maintenance of ploidy in budding yeast and similar mechanisms might exist in higher eukaryotes to ensure faithful asymmetric cell division. Here, we review the current model of SPOC activation and highlight the importance of protein localization and phosphorylation for SPOC function. BioMed Central 2010-12-11 /pmc/articles/PMC3004881/ /pubmed/21143992 http://dx.doi.org/10.1186/1747-1028-5-28 Text en Copyright ©2010 Caydasi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Caydasi, Ayse K Ibrahim, Bashar Pereira, Gislene Monitoring spindle orientation: Spindle position checkpoint in charge |
title | Monitoring spindle orientation: Spindle position checkpoint in charge |
title_full | Monitoring spindle orientation: Spindle position checkpoint in charge |
title_fullStr | Monitoring spindle orientation: Spindle position checkpoint in charge |
title_full_unstemmed | Monitoring spindle orientation: Spindle position checkpoint in charge |
title_short | Monitoring spindle orientation: Spindle position checkpoint in charge |
title_sort | monitoring spindle orientation: spindle position checkpoint in charge |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004881/ https://www.ncbi.nlm.nih.gov/pubmed/21143992 http://dx.doi.org/10.1186/1747-1028-5-28 |
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