Marginal Level Dystrophin Expression Improves Clinical Outcome in a Strain of Dystrophin/Utrophin Double Knockout Mice

Inactivation of all utrophin isoforms in dystrophin-deficient mdx mice results in a strain of utrophin knockout mdx (uko/mdx) mice. Uko/mdx mice display severe clinical symptoms and die prematurely as in Duchenne muscular dystrophy (DMD) patients. Here we tested the hypothesis that marginal level dy...

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Detalles Bibliográficos
Autores principales: Li, Dejia, Yue, Yongping, Duan, Dongsheng
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004926/
https://www.ncbi.nlm.nih.gov/pubmed/21187970
http://dx.doi.org/10.1371/journal.pone.0015286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004926/
https://www.ncbi.nlm.nih.gov/pubmed/21187970
http://dx.doi.org/10.1371/journal.pone.0015286

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