Induced pluripotent stem cell–derived human platelets: one step closer to the clinic

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The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of...

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Detalles Bibliográficos
Autores principales: Gekas, Christos, Graf, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005227/
https://www.ncbi.nlm.nih.gov/pubmed/21173109
http://dx.doi.org/10.1084/jem.20102428
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author Gekas, Christos
Graf, Thomas
author_facet Gekas, Christos
Graf, Thomas
author_sort Gekas, Christos
collection PubMed
description The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells.
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spelling pubmed-30052272011-06-20 Induced pluripotent stem cell–derived human platelets: one step closer to the clinic Gekas, Christos Graf, Thomas J Exp Med Minireview The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells. The Rockefeller University Press 2010-12-20 /pmc/articles/PMC3005227/ /pubmed/21173109 http://dx.doi.org/10.1084/jem.20102428 Text en © 2010 Gekas and Graf This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Minireview
Gekas, Christos
Graf, Thomas
Induced pluripotent stem cell–derived human platelets: one step closer to the clinic
title Induced pluripotent stem cell–derived human platelets: one step closer to the clinic
title_full Induced pluripotent stem cell–derived human platelets: one step closer to the clinic
title_fullStr Induced pluripotent stem cell–derived human platelets: one step closer to the clinic
title_full_unstemmed Induced pluripotent stem cell–derived human platelets: one step closer to the clinic
title_short Induced pluripotent stem cell–derived human platelets: one step closer to the clinic
title_sort induced pluripotent stem cell–derived human platelets: one step closer to the clinic
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005227/
https://www.ncbi.nlm.nih.gov/pubmed/21173109
http://dx.doi.org/10.1084/jem.20102428
work_keys_str_mv AT gekaschristos inducedpluripotentstemcellderivedhumanplateletsonestepclosertotheclinic
AT grafthomas inducedpluripotentstemcellderivedhumanplateletsonestepclosertotheclinic

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