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Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

Sphingosine-1-phosphate (S1P), a lipid mediator enriched in blood, controls the dynamic migration of osteoclast (OC) precursors (OPs) between the blood and bone, in part via the S1P receptor 1 (S1PR1) which directs positive chemotaxis toward S1P. We show that OPs also express S1PR2, an S1P receptor...

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Detalles Bibliográficos
Autores principales:	Ishii, Masaru, Kikuta, Junichi, Shimazu, Yutaka, Meier-Schellersheim, Martin, Germain, Ronald N.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005230/ https://www.ncbi.nlm.nih.gov/pubmed/21135136 http://dx.doi.org/10.1084/jem.20101474

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