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Aspirin-Exacerbated Respiratory Disease: Evaluation and Management
The clinical syndrome of aspirin-exacerbated respiratory disease (AERD) is a condition where inhibition of cyclooxygenase-1 (COX-1) induces attacks of upper and lower airway reactions, including rhinorrhea and varying degrees of bronchospasm and laryngospasm. Although the reaction is not IgE-mediate...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005316/ https://www.ncbi.nlm.nih.gov/pubmed/21217919 http://dx.doi.org/10.4168/aair.2011.3.1.3 |
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author | Lee, Rachel U. Stevenson, Donald D. |
author_facet | Lee, Rachel U. Stevenson, Donald D. |
author_sort | Lee, Rachel U. |
collection | PubMed |
description | The clinical syndrome of aspirin-exacerbated respiratory disease (AERD) is a condition where inhibition of cyclooxygenase-1 (COX-1) induces attacks of upper and lower airway reactions, including rhinorrhea and varying degrees of bronchospasm and laryngospasm. Although the reaction is not IgE-mediated, patients can also present with anaphylactic hypersensitivity reactions, including hypotension, after exposure to COX-1 inhibiting drugs. All patients with AERD have underlying nasal polyps and intractable sinus disease which may be difficult to treat with standard medical and surgical interventions. This review article focuses on the management of AERD patients with a particular emphasis on aspirin desensitization and continuous treatment with aspirin. |
format | Text |
id | pubmed-3005316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-30053162011-01-08 Aspirin-Exacerbated Respiratory Disease: Evaluation and Management Lee, Rachel U. Stevenson, Donald D. Allergy Asthma Immunol Res Review The clinical syndrome of aspirin-exacerbated respiratory disease (AERD) is a condition where inhibition of cyclooxygenase-1 (COX-1) induces attacks of upper and lower airway reactions, including rhinorrhea and varying degrees of bronchospasm and laryngospasm. Although the reaction is not IgE-mediated, patients can also present with anaphylactic hypersensitivity reactions, including hypotension, after exposure to COX-1 inhibiting drugs. All patients with AERD have underlying nasal polyps and intractable sinus disease which may be difficult to treat with standard medical and surgical interventions. This review article focuses on the management of AERD patients with a particular emphasis on aspirin desensitization and continuous treatment with aspirin. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2011-01 2010-08-20 /pmc/articles/PMC3005316/ /pubmed/21217919 http://dx.doi.org/10.4168/aair.2011.3.1.3 Text en Copyright © 2011 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lee, Rachel U. Stevenson, Donald D. Aspirin-Exacerbated Respiratory Disease: Evaluation and Management |
title | Aspirin-Exacerbated Respiratory Disease: Evaluation and Management |
title_full | Aspirin-Exacerbated Respiratory Disease: Evaluation and Management |
title_fullStr | Aspirin-Exacerbated Respiratory Disease: Evaluation and Management |
title_full_unstemmed | Aspirin-Exacerbated Respiratory Disease: Evaluation and Management |
title_short | Aspirin-Exacerbated Respiratory Disease: Evaluation and Management |
title_sort | aspirin-exacerbated respiratory disease: evaluation and management |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005316/ https://www.ncbi.nlm.nih.gov/pubmed/21217919 http://dx.doi.org/10.4168/aair.2011.3.1.3 |
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