Cargando…

Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study

OBJECTIVE: Recent studies suggest that uric acid may predict the development of diabetes in the general population. Whether this association holds true in primary hypertension and is independent of renal function and metabolic syndrome is not clear at present. RESEARCH DESIGN AND METHODS: In a prosp...

Descripción completa

Detalles Bibliográficos
Autores principales: Viazzi, Francesca, Leoncini, Giovanna, Vercelli, Marina, Deferrari, Giacomo, Pontremoli, Roberto
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005465/
https://www.ncbi.nlm.nih.gov/pubmed/20921214
http://dx.doi.org/10.2337/dc10-0918
_version_ 1782194095507111936
author Viazzi, Francesca
Leoncini, Giovanna
Vercelli, Marina
Deferrari, Giacomo
Pontremoli, Roberto
author_facet Viazzi, Francesca
Leoncini, Giovanna
Vercelli, Marina
Deferrari, Giacomo
Pontremoli, Roberto
author_sort Viazzi, Francesca
collection PubMed
description OBJECTIVE: Recent studies suggest that uric acid may predict the development of diabetes in the general population. Whether this association holds true in primary hypertension and is independent of renal function and metabolic syndrome is not clear at present. RESEARCH DESIGN AND METHODS: In a prospective, observational study, 758 untreated hypertensive patients were evaluated at baseline and followed-up for 11 years. RESULTS: A total of 8,332 person-years of follow-up revealed that slightly elevated uric acid levels (i.e., ≥318 μmol/l for women and ≥420 μmol/l for men) at baseline were associated with a significantly higher risk of developing diabetes (hazard ratio 3.65 [95% CI 1.99–6.69], P < 0.0001), even after adjustment for several confounding factors such as metabolic syndrome (2.78 [1.35–5.70], P = 0.0054). CONCLUSIONS: Uric acid is an independent predictor of diabetes in primary hypertension.
format Text
id pubmed-3005465
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-30054652012-01-01 Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study Viazzi, Francesca Leoncini, Giovanna Vercelli, Marina Deferrari, Giacomo Pontremoli, Roberto Diabetes Care Original Research OBJECTIVE: Recent studies suggest that uric acid may predict the development of diabetes in the general population. Whether this association holds true in primary hypertension and is independent of renal function and metabolic syndrome is not clear at present. RESEARCH DESIGN AND METHODS: In a prospective, observational study, 758 untreated hypertensive patients were evaluated at baseline and followed-up for 11 years. RESULTS: A total of 8,332 person-years of follow-up revealed that slightly elevated uric acid levels (i.e., ≥318 μmol/l for women and ≥420 μmol/l for men) at baseline were associated with a significantly higher risk of developing diabetes (hazard ratio 3.65 [95% CI 1.99–6.69], P < 0.0001), even after adjustment for several confounding factors such as metabolic syndrome (2.78 [1.35–5.70], P = 0.0054). CONCLUSIONS: Uric acid is an independent predictor of diabetes in primary hypertension. American Diabetes Association 2011-01 2010-10-04 /pmc/articles/PMC3005465/ /pubmed/20921214 http://dx.doi.org/10.2337/dc10-0918 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Viazzi, Francesca
Leoncini, Giovanna
Vercelli, Marina
Deferrari, Giacomo
Pontremoli, Roberto
Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study
title Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study
title_full Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study
title_fullStr Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study
title_full_unstemmed Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study
title_short Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study
title_sort serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the magic study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005465/
https://www.ncbi.nlm.nih.gov/pubmed/20921214
http://dx.doi.org/10.2337/dc10-0918
work_keys_str_mv AT viazzifrancesca serumuricacidlevelspredictnewonsettype2diabetesinhospitalizedpatientswithprimaryhypertensionthemagicstudy
AT leoncinigiovanna serumuricacidlevelspredictnewonsettype2diabetesinhospitalizedpatientswithprimaryhypertensionthemagicstudy
AT vercellimarina serumuricacidlevelspredictnewonsettype2diabetesinhospitalizedpatientswithprimaryhypertensionthemagicstudy
AT deferrarigiacomo serumuricacidlevelspredictnewonsettype2diabetesinhospitalizedpatientswithprimaryhypertensionthemagicstudy
AT pontremoliroberto serumuricacidlevelspredictnewonsettype2diabetesinhospitalizedpatientswithprimaryhypertensionthemagicstudy