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Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study
OBJECTIVE: Recent studies suggest that uric acid may predict the development of diabetes in the general population. Whether this association holds true in primary hypertension and is independent of renal function and metabolic syndrome is not clear at present. RESEARCH DESIGN AND METHODS: In a prosp...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005465/ https://www.ncbi.nlm.nih.gov/pubmed/20921214 http://dx.doi.org/10.2337/dc10-0918 |
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author | Viazzi, Francesca Leoncini, Giovanna Vercelli, Marina Deferrari, Giacomo Pontremoli, Roberto |
author_facet | Viazzi, Francesca Leoncini, Giovanna Vercelli, Marina Deferrari, Giacomo Pontremoli, Roberto |
author_sort | Viazzi, Francesca |
collection | PubMed |
description | OBJECTIVE: Recent studies suggest that uric acid may predict the development of diabetes in the general population. Whether this association holds true in primary hypertension and is independent of renal function and metabolic syndrome is not clear at present. RESEARCH DESIGN AND METHODS: In a prospective, observational study, 758 untreated hypertensive patients were evaluated at baseline and followed-up for 11 years. RESULTS: A total of 8,332 person-years of follow-up revealed that slightly elevated uric acid levels (i.e., ≥318 μmol/l for women and ≥420 μmol/l for men) at baseline were associated with a significantly higher risk of developing diabetes (hazard ratio 3.65 [95% CI 1.99–6.69], P < 0.0001), even after adjustment for several confounding factors such as metabolic syndrome (2.78 [1.35–5.70], P = 0.0054). CONCLUSIONS: Uric acid is an independent predictor of diabetes in primary hypertension. |
format | Text |
id | pubmed-3005465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-30054652012-01-01 Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study Viazzi, Francesca Leoncini, Giovanna Vercelli, Marina Deferrari, Giacomo Pontremoli, Roberto Diabetes Care Original Research OBJECTIVE: Recent studies suggest that uric acid may predict the development of diabetes in the general population. Whether this association holds true in primary hypertension and is independent of renal function and metabolic syndrome is not clear at present. RESEARCH DESIGN AND METHODS: In a prospective, observational study, 758 untreated hypertensive patients were evaluated at baseline and followed-up for 11 years. RESULTS: A total of 8,332 person-years of follow-up revealed that slightly elevated uric acid levels (i.e., ≥318 μmol/l for women and ≥420 μmol/l for men) at baseline were associated with a significantly higher risk of developing diabetes (hazard ratio 3.65 [95% CI 1.99–6.69], P < 0.0001), even after adjustment for several confounding factors such as metabolic syndrome (2.78 [1.35–5.70], P = 0.0054). CONCLUSIONS: Uric acid is an independent predictor of diabetes in primary hypertension. American Diabetes Association 2011-01 2010-10-04 /pmc/articles/PMC3005465/ /pubmed/20921214 http://dx.doi.org/10.2337/dc10-0918 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Viazzi, Francesca Leoncini, Giovanna Vercelli, Marina Deferrari, Giacomo Pontremoli, Roberto Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study |
title | Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study |
title_full | Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study |
title_fullStr | Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study |
title_full_unstemmed | Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study |
title_short | Serum Uric Acid Levels Predict New-Onset Type 2 Diabetes in Hospitalized Patients With Primary Hypertension: The MAGIC Study |
title_sort | serum uric acid levels predict new-onset type 2 diabetes in hospitalized patients with primary hypertension: the magic study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005465/ https://www.ncbi.nlm.nih.gov/pubmed/20921214 http://dx.doi.org/10.2337/dc10-0918 |
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