Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions

OBJECTIVE: To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS: We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of...

Descripción completa

Detalles Bibliográficos
Autores principales: Roberts, Rosebud O., Kantarci, Kejal, Geda, Yonas E., Knopman, David S., Przybelski, Scott A., Weigand, Stephen D., Petersen, Ronald C., Jack, Clifford R.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005470/
https://www.ncbi.nlm.nih.gov/pubmed/20980413
http://dx.doi.org/10.2337/dc10-0602
Descripción
Sumario:OBJECTIVE: To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS: We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS: The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91–2.75]). The association was stronger in case subjects without treatment (2.60 [1.11–6.08]) and in case subjects with diabetes-related complications (1.96 [1.02–3.74]) compared with control subjects. CONCLUSIONS: These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

Ejemplares similares