Cargando…

Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

OBJECTIVE: Sustained hyperglycemia is associated with low cellular levels of the antioxidant glutathione (GSH), which leads to tissue damage attributed to oxidative stress. We tested the hypothesis that diminished GSH in adult patients with uncontrolled type 2 diabetes is attributed to decreased syn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sekhar, Rajagopal V., McKay, Siripoom V., Patel, Sanjeet G., Guthikonda, Anuradha P., Reddy, Vasumathi T., Balasubramanyam, Ashok, Jahoor, Farook
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005481/ https://www.ncbi.nlm.nih.gov/pubmed/20929994 http://dx.doi.org/10.2337/dc10-1006

Ejemplares similares

GLUTATHIONE DEFICIENCY AND OXIDATIVE STRESS IN AGING: METABOLIC MECHANISM AND TARGETED INTERVENTION
por: Jahoor, Farook, et al.
Publicado: (2019)

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
por: Kumar, Premranjan, et al.
Publicado: (2021)

GLUTATHIONE, MITOCHONDRIAL DEFECTS, AND A UNIQUE METABOLIC CYCLE IN OLDER HUMANS: IMPLICATIONS FOR SARCOPENIA
por: Sekhar, Rajagopal V, et al.
Publicado: (2019)

SUPPLEMENTING GLYNAC IN AGING IMPROVES GLUTATHIONE, MITOCHONDRIA, AND AGING HALLMARKS: A RANDOMIZED CLINICAL TRIAL
por: Sekhar, Rajagopal, et al.
Publicado: (2022)

CORRECTING GLUTATHIONE DEFICIENCY AND MITOCHONDRIAL DYSFUNCTION IN OLDER HUMANS: A RANDOMIZED CLINICAL TRIAL
por: Sekhar, Rajagopal V, et al.
Publicado: (2019)

Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial
por: Kumar, Premranjan, et al.
Publicado: (2020)

Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease
por: Ghezzi, Pietro, et al.
Publicado: (2018)

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage
por: Kumar, Premranjan, et al.
Publicado: (2022)

Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation
por: Kumar, Premranjan, et al.
Publicado: (2021)

HIV-associated adipose redistribution syndrome (HARS): definition, epidemiology and clinical impact
por: Lichtenstein, Kenneth, et al.
Publicado: (2007)

HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
por: Lichtenstein, Kenneth, et al.
Publicado: (2007)

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging
por: Kumar, Premranjan, et al.
Publicado: (2023)

Pathogenesis of A(−)β(+) Ketosis-Prone Diabetes
por: Patel, Sanjeet G., et al.
Publicado: (2013)

GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study
por: Sekhar, Rajagopal V.
Publicado: (2022)

Exogenous glycine promotes oxidation of glutathione and restores sensitivity of bacterial pathogens to serum-induced cell death
por: Kou, Tian-shun, et al.
Publicado: (2022)

De Novo Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery
por: Tan, Hong Chang, et al.
Publicado: (2022)

Subcellular distribution of glutathione and cysteine in cyanobacteria
por: Zechmann, Bernd, et al.
Publicado: (2010)

Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia
por: Lutchmansingh, Fallon K., et al.
Publicado: (2018)

Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins
por: Yao, Chunxiang, et al.
Publicado: (2015)

CORRECTING GLUTATHIONE DEFICIENCY REVERSES MITOCHONDRIAL DYSFUNCTION AND ACCELERATED AGING IN PATIENTS WITH HIV
por: Sekhar, Rajagopal V, et al.
Publicado: (2019)

Cysteine, Glutathione, and Thiol Redox Balance in Astrocytes
por: McBean, Gethin J.
Publicado: (2017)

Cysteinyl-glycine in the control of glutathione homeostasis in bovine lenses
por: De Donatis, Gian Marco, et al.
Publicado: (2010)

CORRECTING GLUTATHIONE DEFICIENCY IN AGING: IMPACT ON MITOCHONDRIA, STRENGTH, INFLAMMATION AND METABOLIC DEFECTS
por: Sekhar, Rajagopal, et al.
Publicado: (2019)

N-Acetyl Cysteine Restores the Diminished Activity of the Antioxidant Enzymatic System Caused by SARS-CoV-2 Infection: Preliminary Findings
por: Soto, María Elena, et al.
Publicado: (2023)

Serum Branch Chain Amino Acids (BCAAs) Are Elevated Due to Decreased Catabolism in Patients With Ketosis-Prone Diabetes at the Time of Presentation With DKA
por: Hsu, Jean Wei, et al.
Publicado: (2021)

Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis
por: Rom, Oren, et al.
Publicado: (2022)

Effects of Glutathione Diminishment on the Immune Responses against Mycobacterium tuberculosis Infection
por: Cao, Ruoqiong, et al.
Publicado: (2021)

A−β− Subtype of Ketosis-Prone Diabetes Is Not Predominantly a Monogenic Diabetic Syndrome
por: Haaland, Wade C., et al.
Publicado: (2009)

The still mysterious roles of cysteine-containing glutathione transferases in plants
por: Lallement, Pierre-Alexandre, et al.
Publicado: (2014)

Effects of 1,25-Dihydroxycholecalciferol on Recovery and Resolution of Late Transient Neonatal Hypocalcemia
por: Amaral, Jennifer M., et al.
Publicado: (2010)

Insight into Improved Thermostability of Cold-Adapted Staphylococcal Lipase by Glycine to Cysteine Mutation
por: Veno, Jiivittha, et al.
Publicado: (2019)

Glycine induced acute transient postoperative visual loss
por: Pramod, Anita, et al.
Publicado: (2015)

Cytosolic Triosephosphate Isomerase from Arabidopsis thaliana Is Reversibly Modified by Glutathione on Cysteines 127 and 218
por: Dumont, Sébastien, et al.
Publicado: (2016)

Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance
por: Xia, Jiliang, et al.
Publicado: (2022)

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione
por: Pem, Barbara, et al.
Publicado: (2019)

A DFT Study of the Reaction of Acrylamide with L-Cysteine and L-Glutathione
por: Ramirez-Montes, Sandra, et al.
Publicado: (2022)

Revisiting the pro-oxidant activity of copper: interplay of ascorbate, cysteine, and glutathione
por: Falcone, Enrico, et al.
Publicado: (2023)

Role of L2 cysteines in papillomavirus infection and neutralization
por: Gambhira, Ratish, et al.
Publicado: (2009)

Ginsentides: Cysteine and Glycine-rich Peptides from the Ginseng Family with Unusual Disulfide Connectivity
por: Tam, James P., et al.
Publicado: (2018)

Cross-Linking and Functional Analyses for Dimerization of a Cysteine Mutant of Glycine Transporter 1
por: Wang, Jingru, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_va942oaf61msd5eg1th74pp921