Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)

The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes ch...

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Autores principales: Pedicelli, Stefania, Peschiaroli, Emanuela, Violi, Enrica, Cianfarani, Stefano
Formato: Texto
Lenguaje:English
Publicado: Galenos Publishing 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005647/
https://www.ncbi.nlm.nih.gov/pubmed/21274395
http://dx.doi.org/10.4008/jcrpe.v1i3.53
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author Pedicelli, Stefania
Peschiaroli, Emanuela
Violi, Enrica
Cianfarani, Stefano
author_facet Pedicelli, Stefania
Peschiaroli, Emanuela
Violi, Enrica
Cianfarani, Stefano
author_sort Pedicelli, Stefania
collection PubMed
description The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes children with constitutional delay of growth and puberty, familial short stature, or both, as well as those with subtle cartilage and bone dysplasias. In rare cases, ISS is due to IGF molecular abnormalities. In this review we tackle the major challenges in the definition and treatment of ISS. Conflict of interest:None declared.
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spelling pubmed-30056472011-01-27 Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS) Pedicelli, Stefania Peschiaroli, Emanuela Violi, Enrica Cianfarani, Stefano J Clin Res Pediatr Endocrinol Review The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes children with constitutional delay of growth and puberty, familial short stature, or both, as well as those with subtle cartilage and bone dysplasias. In rare cases, ISS is due to IGF molecular abnormalities. In this review we tackle the major challenges in the definition and treatment of ISS. Conflict of interest:None declared. Galenos Publishing 2009-03 2009-02-01 /pmc/articles/PMC3005647/ /pubmed/21274395 http://dx.doi.org/10.4008/jcrpe.v1i3.53 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Pedicelli, Stefania
Peschiaroli, Emanuela
Violi, Enrica
Cianfarani, Stefano
Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
title Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
title_full Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
title_fullStr Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
title_full_unstemmed Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
title_short Controversies in the Definition and Treatment of Idiopathic Short Stature (ISS)
title_sort controversies in the definition and treatment of idiopathic short stature (iss)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005647/
https://www.ncbi.nlm.nih.gov/pubmed/21274395
http://dx.doi.org/10.4008/jcrpe.v1i3.53
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AT violienrica controversiesinthedefinitionandtreatmentofidiopathicshortstatureiss
AT cianfaranistefano controversiesinthedefinitionandtreatmentofidiopathicshortstatureiss

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