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Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life. Methods: The study included 60 babies (27 girls and 33 boys) bo...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005658/ https://www.ncbi.nlm.nih.gov/pubmed/21274334 http://dx.doi.org/10.4274/jcrpe.v2i1.34 |
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author | Fidancı, Kürşad Meral, Cihan Süleymanoğlu, Selami Pirgon, Özgür Karademir, Ferhan Aydınöz, Seçil Özkaya, Halit Gültepe, Mustafa Göçmen, İsmail |
author_facet | Fidancı, Kürşad Meral, Cihan Süleymanoğlu, Selami Pirgon, Özgür Karademir, Ferhan Aydınöz, Seçil Özkaya, Halit Gültepe, Mustafa Göçmen, İsmail |
author_sort | Fidancı, Kürşad |
collection | PubMed |
description | Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life. Methods: The study included 60 babies (27 girls and 33 boys) born at gestational ages between 38-42 weeks. The newborns were divided into three groups according to the Lubchenco curves as: small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). The relationship between ghrelin levels and growth parameters in the third month was investigated. Results: Ghrelin concentrations were significantly higher in SGA (2.4±2.6 ng/dL) babies than in AGA (1.3±0.9 ng/dL) and LGA (1.0±0.8 ng/dL) babies. The lowest ghrelin levels were in the LGA group. In SGA infants, ghrelin concentrations were inversely correlated with change in weight (r=-0.577; p=0.001), change in length (r=-0.361; p=0.005), and change in head circumference (r=-0.387; p=0.002). Conclusion: The results show that at age 3 months, SGA infants had higher ghrelin levels than AGA and LGA infants. Our findings indicate that ghrelin may be involved in the process of catch-up growth in these infants. Conflict of interest:None declared. |
format | Text |
id | pubmed-3005658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-30056582011-01-27 Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age Fidancı, Kürşad Meral, Cihan Süleymanoğlu, Selami Pirgon, Özgür Karademir, Ferhan Aydınöz, Seçil Özkaya, Halit Gültepe, Mustafa Göçmen, İsmail J Clin Res Pediatr Endocrinol Original Article Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life. Methods: The study included 60 babies (27 girls and 33 boys) born at gestational ages between 38-42 weeks. The newborns were divided into three groups according to the Lubchenco curves as: small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). The relationship between ghrelin levels and growth parameters in the third month was investigated. Results: Ghrelin concentrations were significantly higher in SGA (2.4±2.6 ng/dL) babies than in AGA (1.3±0.9 ng/dL) and LGA (1.0±0.8 ng/dL) babies. The lowest ghrelin levels were in the LGA group. In SGA infants, ghrelin concentrations were inversely correlated with change in weight (r=-0.577; p=0.001), change in length (r=-0.361; p=0.005), and change in head circumference (r=-0.387; p=0.002). Conclusion: The results show that at age 3 months, SGA infants had higher ghrelin levels than AGA and LGA infants. Our findings indicate that ghrelin may be involved in the process of catch-up growth in these infants. Conflict of interest:None declared. Galenos Publishing 2010-03 2010-12-08 /pmc/articles/PMC3005658/ /pubmed/21274334 http://dx.doi.org/10.4274/jcrpe.v2i1.34 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Fidancı, Kürşad Meral, Cihan Süleymanoğlu, Selami Pirgon, Özgür Karademir, Ferhan Aydınöz, Seçil Özkaya, Halit Gültepe, Mustafa Göçmen, İsmail Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age |
title | Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age |
title_full | Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age |
title_fullStr | Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age |
title_full_unstemmed | Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age |
title_short | Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age |
title_sort | ghrelin levels and postnatal growth in healthy infants 0-3 months of age |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005658/ https://www.ncbi.nlm.nih.gov/pubmed/21274334 http://dx.doi.org/10.4274/jcrpe.v2i1.34 |
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