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Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age

Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life. Methods: The study included 60 babies (27 girls and 33 boys) bo...

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Autores principales: Fidancı, Kürşad, Meral, Cihan, Süleymanoğlu, Selami, Pirgon, Özgür, Karademir, Ferhan, Aydınöz, Seçil, Özkaya, Halit, Gültepe, Mustafa, Göçmen, İsmail
Formato: Texto
Lenguaje:English
Publicado: Galenos Publishing 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005658/
https://www.ncbi.nlm.nih.gov/pubmed/21274334
http://dx.doi.org/10.4274/jcrpe.v2i1.34
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author Fidancı, Kürşad
Meral, Cihan
Süleymanoğlu, Selami
Pirgon, Özgür
Karademir, Ferhan
Aydınöz, Seçil
Özkaya, Halit
Gültepe, Mustafa
Göçmen, İsmail
author_facet Fidancı, Kürşad
Meral, Cihan
Süleymanoğlu, Selami
Pirgon, Özgür
Karademir, Ferhan
Aydınöz, Seçil
Özkaya, Halit
Gültepe, Mustafa
Göçmen, İsmail
author_sort Fidancı, Kürşad
collection PubMed
description Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life. Methods: The study included 60 babies (27 girls and 33 boys) born at gestational ages between 38-42 weeks. The newborns were divided into three groups according to the Lubchenco curves as: small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). The relationship between ghrelin levels and growth parameters in the third month was investigated. Results: Ghrelin concentrations were significantly higher in SGA (2.4±2.6 ng/dL) babies than in AGA (1.3±0.9 ng/dL) and LGA (1.0±0.8 ng/dL) babies. The lowest ghrelin levels were in the LGA group. In SGA infants, ghrelin concentrations were inversely correlated with change in weight (r=-0.577; p=0.001), change in length (r=-0.361; p=0.005), and change in head circumference (r=-0.387; p=0.002). Conclusion: The results show that at age 3 months, SGA infants had higher ghrelin levels than AGA and LGA infants. Our findings indicate that ghrelin may be involved in the process of catch-up growth in these infants. Conflict of interest:None declared.
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spelling pubmed-30056582011-01-27 Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age Fidancı, Kürşad Meral, Cihan Süleymanoğlu, Selami Pirgon, Özgür Karademir, Ferhan Aydınöz, Seçil Özkaya, Halit Gültepe, Mustafa Göçmen, İsmail J Clin Res Pediatr Endocrinol Original Article Objective: The effect of ghrelin on growth of the newborn has long been argued, but not fully clarified. In this study, we aimed to investigate the relationship between ghrelin levels and growth parameters in the first 3 months of life. Methods: The study included 60 babies (27 girls and 33 boys) born at gestational ages between 38-42 weeks. The newborns were divided into three groups according to the Lubchenco curves as: small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). The relationship between ghrelin levels and growth parameters in the third month was investigated. Results: Ghrelin concentrations were significantly higher in SGA (2.4±2.6 ng/dL) babies than in AGA (1.3±0.9 ng/dL) and LGA (1.0±0.8 ng/dL) babies. The lowest ghrelin levels were in the LGA group. In SGA infants, ghrelin concentrations were inversely correlated with change in weight (r=-0.577; p=0.001), change in length (r=-0.361; p=0.005), and change in head circumference (r=-0.387; p=0.002). Conclusion: The results show that at age 3 months, SGA infants had higher ghrelin levels than AGA and LGA infants. Our findings indicate that ghrelin may be involved in the process of catch-up growth in these infants. Conflict of interest:None declared. Galenos Publishing 2010-03 2010-12-08 /pmc/articles/PMC3005658/ /pubmed/21274334 http://dx.doi.org/10.4274/jcrpe.v2i1.34 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fidancı, Kürşad
Meral, Cihan
Süleymanoğlu, Selami
Pirgon, Özgür
Karademir, Ferhan
Aydınöz, Seçil
Özkaya, Halit
Gültepe, Mustafa
Göçmen, İsmail
Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
title Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
title_full Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
title_fullStr Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
title_full_unstemmed Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
title_short Ghrelin Levels and Postnatal Growth in Healthy Infants 0-3 Months of Age
title_sort ghrelin levels and postnatal growth in healthy infants 0-3 months of age
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005658/
https://www.ncbi.nlm.nih.gov/pubmed/21274334
http://dx.doi.org/10.4274/jcrpe.v2i1.34
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