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Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report

Neonatal diabetes mellitus (DM) develops within the first six weeks of life with basic findings including dehydration, hyperglycaemia, and mild or no ketonemia/ketonuria. It can be either transient or permanent. Here, we report a case of a one−month−old infant with permanent neonatal diabetes, due t...

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Autores principales: Abacı, Ayhan, Razi, Cem Hasan, Özdemir, Osman, Hızlı, Samil, Kıslal, Fatih, Argas, Pınar Işık, Kabakuş, Nimet
Formato: Texto
Lenguaje:English
Publicado: Galenos Publishing 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005678/
https://www.ncbi.nlm.nih.gov/pubmed/21274328
http://dx.doi.org/10.4274/jcrpe.v2i3.131
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author Abacı, Ayhan
Razi, Cem Hasan
Özdemir, Osman
Hızlı, Samil
Kıslal, Fatih
Argas, Pınar Işık
Kabakuş, Nimet
author_facet Abacı, Ayhan
Razi, Cem Hasan
Özdemir, Osman
Hızlı, Samil
Kıslal, Fatih
Argas, Pınar Işık
Kabakuş, Nimet
author_sort Abacı, Ayhan
collection PubMed
description Neonatal diabetes mellitus (DM) develops within the first six weeks of life with basic findings including dehydration, hyperglycaemia, and mild or no ketonemia/ketonuria. It can be either transient or permanent. Here, we report a case of a one−month−old infant with permanent neonatal diabetes, due to pancreatic hypoplasia, accompanied by diabetic ketoacidosis (DKA). The hyperglycaemia and ketoacidosis resolved by the 14(th) hour of treatment, consisting of IV insulin and rehydration. Subsequently, insulin treatment was continued with neutral protamine hagedorn (NPH) insulin. Breastfeeding was started and was continued at intervals of three hours. Following initiation of breastfeeding, the stools became watery, loose, yellow−green in color, and frequent (8−10 times a day). They contained no blood or mucus. Replacement of pancreatic enzymes resulted in decreased stool frequency. Neonatal DM due to pancreatic hypoplasia and associated with DKA may mimic sepsis and should be kept in mind in all newborns who present with fever, dehydration, and weight loss. Conflict of interest:None declared.
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spelling pubmed-30056782011-01-27 Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report Abacı, Ayhan Razi, Cem Hasan Özdemir, Osman Hızlı, Samil Kıslal, Fatih Argas, Pınar Işık Kabakuş, Nimet J Clin Res Pediatr Endocrinol Case Reports Neonatal diabetes mellitus (DM) develops within the first six weeks of life with basic findings including dehydration, hyperglycaemia, and mild or no ketonemia/ketonuria. It can be either transient or permanent. Here, we report a case of a one−month−old infant with permanent neonatal diabetes, due to pancreatic hypoplasia, accompanied by diabetic ketoacidosis (DKA). The hyperglycaemia and ketoacidosis resolved by the 14(th) hour of treatment, consisting of IV insulin and rehydration. Subsequently, insulin treatment was continued with neutral protamine hagedorn (NPH) insulin. Breastfeeding was started and was continued at intervals of three hours. Following initiation of breastfeeding, the stools became watery, loose, yellow−green in color, and frequent (8−10 times a day). They contained no blood or mucus. Replacement of pancreatic enzymes resulted in decreased stool frequency. Neonatal DM due to pancreatic hypoplasia and associated with DKA may mimic sepsis and should be kept in mind in all newborns who present with fever, dehydration, and weight loss. Conflict of interest:None declared. Galenos Publishing 2010-09 2010-08-08 /pmc/articles/PMC3005678/ /pubmed/21274328 http://dx.doi.org/10.4274/jcrpe.v2i3.131 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Abacı, Ayhan
Razi, Cem Hasan
Özdemir, Osman
Hızlı, Samil
Kıslal, Fatih
Argas, Pınar Işık
Kabakuş, Nimet
Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report
title Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report
title_full Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report
title_fullStr Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report
title_full_unstemmed Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report
title_short Neonatal Diabetes Mellitus Accompanied by Diabetic Ketoacidosis and Mimicking Neonatal Sepsis: A Case Report
title_sort neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005678/
https://www.ncbi.nlm.nih.gov/pubmed/21274328
http://dx.doi.org/10.4274/jcrpe.v2i3.131
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