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Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels

Objective: The aim of this study was to investigate the effect of hypo− and euthyroid status on serum cystatin C (CysC) levels in children and to explore whether CysC can be used as a marker of the thyroid status. Methods: Twenty five patients with hypothyroidism (10M, 15F; mean age:8.7±4.9 years) a...

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Autores principales: Özden, Tülin Ayşe, Tekerek, Hüseyin, Baş, Firdevs, Darendeliler, Feyza
Formato: Texto
Lenguaje:English
Publicado: Galenos Publishing 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005688/
https://www.ncbi.nlm.nih.gov/pubmed/21274315
http://dx.doi.org/10.4274/jcrpe.v2i4.155
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author Özden, Tülin Ayşe
Tekerek, Hüseyin
Baş, Firdevs
Darendeliler, Feyza
author_facet Özden, Tülin Ayşe
Tekerek, Hüseyin
Baş, Firdevs
Darendeliler, Feyza
author_sort Özden, Tülin Ayşe
collection PubMed
description Objective: The aim of this study was to investigate the effect of hypo− and euthyroid status on serum cystatin C (CysC) levels in children and to explore whether CysC can be used as a marker of the thyroid status. Methods: Twenty five patients with hypothyroidism (10M, 15F; mean age:8.7±4.9 years) and 21 healhty age−matched controls (9M, 12F; mean age: 9.7±5.0 years) were included in this study. Serum thyrotropin (TSH), free thyroxine (fT4), serum CysC and creatinine levels were studied in patients with hypothyroidism twice, i.e. in the euthyroid (on L−T4) and hypothyroid state, and in controls. Results: No significant differences in creatinine, glomerular filtration rate (GFR) and CysC levels were observed between the study group in the euthyroid status and the control group. CysC (mg/dL) level was found to be lower in the hypothyroid status(0.6±0.1) than in the euthyroid status (0.66±0.1) (p=0.01). In hypothyroid status, CysC levels showed a positive correlation with GFR (r=0.463, p=0.02) and GFR had positive correlation with fT4 (r=0.563, p=0.012). Conclusions: We demonstrated a significant effect of thyroid dysfunction on CysC levels, but the changes in serum CysC levels in hypo− and euthyroid status did not exceed the reference interval. It may be concluded that serum CysC levels have limited use in evaluating the peripheral effects of thyroid hormones. Conflict of interest:None declared.
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spelling pubmed-30056882011-01-27 Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels Özden, Tülin Ayşe Tekerek, Hüseyin Baş, Firdevs Darendeliler, Feyza J Clin Res Pediatr Endocrinol Original Article Objective: The aim of this study was to investigate the effect of hypo− and euthyroid status on serum cystatin C (CysC) levels in children and to explore whether CysC can be used as a marker of the thyroid status. Methods: Twenty five patients with hypothyroidism (10M, 15F; mean age:8.7±4.9 years) and 21 healhty age−matched controls (9M, 12F; mean age: 9.7±5.0 years) were included in this study. Serum thyrotropin (TSH), free thyroxine (fT4), serum CysC and creatinine levels were studied in patients with hypothyroidism twice, i.e. in the euthyroid (on L−T4) and hypothyroid state, and in controls. Results: No significant differences in creatinine, glomerular filtration rate (GFR) and CysC levels were observed between the study group in the euthyroid status and the control group. CysC (mg/dL) level was found to be lower in the hypothyroid status(0.6±0.1) than in the euthyroid status (0.66±0.1) (p=0.01). In hypothyroid status, CysC levels showed a positive correlation with GFR (r=0.463, p=0.02) and GFR had positive correlation with fT4 (r=0.563, p=0.012). Conclusions: We demonstrated a significant effect of thyroid dysfunction on CysC levels, but the changes in serum CysC levels in hypo− and euthyroid status did not exceed the reference interval. It may be concluded that serum CysC levels have limited use in evaluating the peripheral effects of thyroid hormones. Conflict of interest:None declared. Galenos Publishing 2010-12 2010-11-04 /pmc/articles/PMC3005688/ /pubmed/21274315 http://dx.doi.org/10.4274/jcrpe.v2i4.155 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Özden, Tülin Ayşe
Tekerek, Hüseyin
Baş, Firdevs
Darendeliler, Feyza
Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels
title Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels
title_full Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels
title_fullStr Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels
title_full_unstemmed Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels
title_short Effect Of Hypo−and Euthyroid Status On Serum Cystatin C Levels
title_sort effect of hypo−and euthyroid status on serum cystatin c levels
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005688/
https://www.ncbi.nlm.nih.gov/pubmed/21274315
http://dx.doi.org/10.4274/jcrpe.v2i4.155
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