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The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets
Objective: Adiponectin and its receptors are known to be expressed in osteoblasts and may have important functions in normal bone cells. The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR). Methods:...
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Formato: | Texto |
Lenguaje: | English |
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Galenos Publishing
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005753/ https://www.ncbi.nlm.nih.gov/pubmed/21274306 http://dx.doi.org/10.4274/jcrpe.v1i6.262 |
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author | Özkan, Behzat Döneray, Hakan Keskin, Halil |
author_facet | Özkan, Behzat Döneray, Hakan Keskin, Halil |
author_sort | Özkan, Behzat |
collection | PubMed |
description | Objective: Adiponectin and its receptors are known to be expressed in osteoblasts and may have important functions in normal bone cells. The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR). Methods: 21 patients with VDDR were included in the study. Patients were treated with 300,000 U D3 (IM) and calcium lactate (50mg/kg/ day, PO, for 10 days). Anthropometric parameters and serum biochemical markers including calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), intact parathormone (iPTH), 25-hydroxyvitamin D (25(OH)D), and adiponectin levels were measured before and after one month of therapy. Results: Weight and length, but not BMI, increased significantly after treatment. Serum 25(OH)D level increased significantly after treatment, while serum adiponectin level decreased (4.21±1.84 vs 52.73±17.63 ng/ml, p<0.000; 150.1±66.14 vs 84.29±9.06 mg/ml, p<0.000, respectively). No significant correlations were found between serum adiponectin and 25(OH)D levels before and after treatment or between delta adiponectin concentrations and delta 25(OH)D levels. Conclusion: Serum adiponectin levels are increased in patients with VDDR, a finding which is probably related to increased osteoblastic activity. Conflict of interest:None declared. |
format | Text |
id | pubmed-3005753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-30057532011-01-27 The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets Özkan, Behzat Döneray, Hakan Keskin, Halil J Clin Res Pediatr Endocrinol Original Article Objective: Adiponectin and its receptors are known to be expressed in osteoblasts and may have important functions in normal bone cells. The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR). Methods: 21 patients with VDDR were included in the study. Patients were treated with 300,000 U D3 (IM) and calcium lactate (50mg/kg/ day, PO, for 10 days). Anthropometric parameters and serum biochemical markers including calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), intact parathormone (iPTH), 25-hydroxyvitamin D (25(OH)D), and adiponectin levels were measured before and after one month of therapy. Results: Weight and length, but not BMI, increased significantly after treatment. Serum 25(OH)D level increased significantly after treatment, while serum adiponectin level decreased (4.21±1.84 vs 52.73±17.63 ng/ml, p<0.000; 150.1±66.14 vs 84.29±9.06 mg/ml, p<0.000, respectively). No significant correlations were found between serum adiponectin and 25(OH)D levels before and after treatment or between delta adiponectin concentrations and delta 25(OH)D levels. Conclusion: Serum adiponectin levels are increased in patients with VDDR, a finding which is probably related to increased osteoblastic activity. Conflict of interest:None declared. Galenos Publishing 2009-12 2010-12-08 /pmc/articles/PMC3005753/ /pubmed/21274306 http://dx.doi.org/10.4274/jcrpe.v1i6.262 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Özkan, Behzat Döneray, Hakan Keskin, Halil The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets |
title | The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets |
title_full | The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets |
title_fullStr | The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets |
title_full_unstemmed | The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets |
title_short | The Effect of Vitamin D Treatment on Serum Adiponectin Levels in Children with Vitamin D Deficiency Rickets |
title_sort | effect of vitamin d treatment on serum adiponectin levels in children with vitamin d deficiency rickets |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005753/ https://www.ncbi.nlm.nih.gov/pubmed/21274306 http://dx.doi.org/10.4274/jcrpe.v1i6.262 |
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