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The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu

Sufu (Suppressor of Fused), a two-domain protein, plays a critical role in regulating Hedgehog signaling and is conserved from flies to humans. A few bacterial Sufu-like proteins have previously been identified based on sequence similarity to the N-terminal domain of eukaryotic Sufu proteins, but no...

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Autores principales: Das, Debanu, Finn, Robert D, Abdubek, Polat, Astakhova, Tamara, Axelrod, Herbert L, Bakolitsa, Constantina, Cai, Xiaohui, Carlton, Dennis, Chen, Connie, Chiu, Hsiu-Ju, Chiu, Michelle, Clayton, Thomas, Deller, Marc C, Duan, Lian, Ellrott, Kyle, Farr, Carol L, Feuerhelm, Julie, Grant, Joanna C, Grzechnik, Anna, Han, Gye Won, Jaroszewski, Lukasz, Jin, Kevin K, Klock, Heath E, Knuth, Mark W, Kozbial, Piotr, Sri Krishna, S, Kumar, Abhinav, Lam, Winnie W, Marciano, David, Miller, Mitchell D, Morse, Andrew T, Nigoghossian, Edward, Nopakun, Amanda, Okach, Linda, Puckett, Christina, Reyes, Ron, Tien, Henry J, Trame, Christine B, van den Bedem, Henry, Weekes, Dana, Wooten, Tiffany, Xu, Qingping, Yeh, Andrew, Zhou, Jiadong, Hodgson, Keith O, Wooley, John, Elsliger, Marc-André, Deacon, Ashley M, Godzik, Adam, Lesley, Scott A, Wilson, Ian A
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005784/
https://www.ncbi.nlm.nih.gov/pubmed/20836087
http://dx.doi.org/10.1002/pro.497
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author Das, Debanu
Finn, Robert D
Abdubek, Polat
Astakhova, Tamara
Axelrod, Herbert L
Bakolitsa, Constantina
Cai, Xiaohui
Carlton, Dennis
Chen, Connie
Chiu, Hsiu-Ju
Chiu, Michelle
Clayton, Thomas
Deller, Marc C
Duan, Lian
Ellrott, Kyle
Farr, Carol L
Feuerhelm, Julie
Grant, Joanna C
Grzechnik, Anna
Han, Gye Won
Jaroszewski, Lukasz
Jin, Kevin K
Klock, Heath E
Knuth, Mark W
Kozbial, Piotr
Sri Krishna, S
Kumar, Abhinav
Lam, Winnie W
Marciano, David
Miller, Mitchell D
Morse, Andrew T
Nigoghossian, Edward
Nopakun, Amanda
Okach, Linda
Puckett, Christina
Reyes, Ron
Tien, Henry J
Trame, Christine B
van den Bedem, Henry
Weekes, Dana
Wooten, Tiffany
Xu, Qingping
Yeh, Andrew
Zhou, Jiadong
Hodgson, Keith O
Wooley, John
Elsliger, Marc-André
Deacon, Ashley M
Godzik, Adam
Lesley, Scott A
Wilson, Ian A
author_facet Das, Debanu
Finn, Robert D
Abdubek, Polat
Astakhova, Tamara
Axelrod, Herbert L
Bakolitsa, Constantina
Cai, Xiaohui
Carlton, Dennis
Chen, Connie
Chiu, Hsiu-Ju
Chiu, Michelle
Clayton, Thomas
Deller, Marc C
Duan, Lian
Ellrott, Kyle
Farr, Carol L
Feuerhelm, Julie
Grant, Joanna C
Grzechnik, Anna
Han, Gye Won
Jaroszewski, Lukasz
Jin, Kevin K
Klock, Heath E
Knuth, Mark W
Kozbial, Piotr
Sri Krishna, S
Kumar, Abhinav
Lam, Winnie W
Marciano, David
Miller, Mitchell D
Morse, Andrew T
Nigoghossian, Edward
Nopakun, Amanda
Okach, Linda
Puckett, Christina
Reyes, Ron
Tien, Henry J
Trame, Christine B
van den Bedem, Henry
Weekes, Dana
Wooten, Tiffany
Xu, Qingping
Yeh, Andrew
Zhou, Jiadong
Hodgson, Keith O
Wooley, John
Elsliger, Marc-André
Deacon, Ashley M
Godzik, Adam
Lesley, Scott A
Wilson, Ian A
author_sort Das, Debanu
collection PubMed
description Sufu (Suppressor of Fused), a two-domain protein, plays a critical role in regulating Hedgehog signaling and is conserved from flies to humans. A few bacterial Sufu-like proteins have previously been identified based on sequence similarity to the N-terminal domain of eukaryotic Sufu proteins, but none have been structurally or biochemically characterized and their function in bacteria is unknown. We have determined the crystal structure of a more distantly related Sufu-like homolog, NGO1391 from Neisseria gonorrhoeae, at 1.4 Å resolution, which provides the first biophysical characterization of a bacterial Sufu-like protein. The structure revealed a striking similarity to the N-terminal domain of human Sufu (r.m.s.d. of 2.6 Å over 93% of the NGO1391 protein), despite an extremely low sequence identity of ∼15%. Subsequent sequence analysis revealed that NGO1391 defines a new subset of smaller, Sufu-like proteins that are present in ∼200 bacterial species and has resulted in expansion of the SUFU (PF05076) family in Pfam.
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spelling pubmed-30057842011-02-14 The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu Das, Debanu Finn, Robert D Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Bakolitsa, Constantina Cai, Xiaohui Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C Duan, Lian Ellrott, Kyle Farr, Carol L Feuerhelm, Julie Grant, Joanna C Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K Klock, Heath E Knuth, Mark W Kozbial, Piotr Sri Krishna, S Kumar, Abhinav Lam, Winnie W Marciano, David Miller, Mitchell D Morse, Andrew T Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J Trame, Christine B van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Yeh, Andrew Zhou, Jiadong Hodgson, Keith O Wooley, John Elsliger, Marc-André Deacon, Ashley M Godzik, Adam Lesley, Scott A Wilson, Ian A Protein Sci Article Sufu (Suppressor of Fused), a two-domain protein, plays a critical role in regulating Hedgehog signaling and is conserved from flies to humans. A few bacterial Sufu-like proteins have previously been identified based on sequence similarity to the N-terminal domain of eukaryotic Sufu proteins, but none have been structurally or biochemically characterized and their function in bacteria is unknown. We have determined the crystal structure of a more distantly related Sufu-like homolog, NGO1391 from Neisseria gonorrhoeae, at 1.4 Å resolution, which provides the first biophysical characterization of a bacterial Sufu-like protein. The structure revealed a striking similarity to the N-terminal domain of human Sufu (r.m.s.d. of 2.6 Å over 93% of the NGO1391 protein), despite an extremely low sequence identity of ∼15%. Subsequent sequence analysis revealed that NGO1391 defines a new subset of smaller, Sufu-like proteins that are present in ∼200 bacterial species and has resulted in expansion of the SUFU (PF05076) family in Pfam. Wiley Subscription Services, Inc., A Wiley Company 2010-11 2010-09-10 /pmc/articles/PMC3005784/ /pubmed/20836087 http://dx.doi.org/10.1002/pro.497 Text en Copyright © 2010 The Protein Society
spellingShingle Article
Das, Debanu
Finn, Robert D
Abdubek, Polat
Astakhova, Tamara
Axelrod, Herbert L
Bakolitsa, Constantina
Cai, Xiaohui
Carlton, Dennis
Chen, Connie
Chiu, Hsiu-Ju
Chiu, Michelle
Clayton, Thomas
Deller, Marc C
Duan, Lian
Ellrott, Kyle
Farr, Carol L
Feuerhelm, Julie
Grant, Joanna C
Grzechnik, Anna
Han, Gye Won
Jaroszewski, Lukasz
Jin, Kevin K
Klock, Heath E
Knuth, Mark W
Kozbial, Piotr
Sri Krishna, S
Kumar, Abhinav
Lam, Winnie W
Marciano, David
Miller, Mitchell D
Morse, Andrew T
Nigoghossian, Edward
Nopakun, Amanda
Okach, Linda
Puckett, Christina
Reyes, Ron
Tien, Henry J
Trame, Christine B
van den Bedem, Henry
Weekes, Dana
Wooten, Tiffany
Xu, Qingping
Yeh, Andrew
Zhou, Jiadong
Hodgson, Keith O
Wooley, John
Elsliger, Marc-André
Deacon, Ashley M
Godzik, Adam
Lesley, Scott A
Wilson, Ian A
The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu
title The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu
title_full The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu
title_fullStr The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu
title_full_unstemmed The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu
title_short The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu
title_sort crystal structure of a bacterial sufu-like protein defines a novel group of bacterial proteins that are similar to the n-terminal domain of human sufu
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005784/
https://www.ncbi.nlm.nih.gov/pubmed/20836087
http://dx.doi.org/10.1002/pro.497
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