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The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu
Sufu (Suppressor of Fused), a two-domain protein, plays a critical role in regulating Hedgehog signaling and is conserved from flies to humans. A few bacterial Sufu-like proteins have previously been identified based on sequence similarity to the N-terminal domain of eukaryotic Sufu proteins, but no...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005784/ https://www.ncbi.nlm.nih.gov/pubmed/20836087 http://dx.doi.org/10.1002/pro.497 |
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author | Das, Debanu Finn, Robert D Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Bakolitsa, Constantina Cai, Xiaohui Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C Duan, Lian Ellrott, Kyle Farr, Carol L Feuerhelm, Julie Grant, Joanna C Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K Klock, Heath E Knuth, Mark W Kozbial, Piotr Sri Krishna, S Kumar, Abhinav Lam, Winnie W Marciano, David Miller, Mitchell D Morse, Andrew T Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J Trame, Christine B van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Yeh, Andrew Zhou, Jiadong Hodgson, Keith O Wooley, John Elsliger, Marc-André Deacon, Ashley M Godzik, Adam Lesley, Scott A Wilson, Ian A |
author_facet | Das, Debanu Finn, Robert D Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Bakolitsa, Constantina Cai, Xiaohui Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C Duan, Lian Ellrott, Kyle Farr, Carol L Feuerhelm, Julie Grant, Joanna C Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K Klock, Heath E Knuth, Mark W Kozbial, Piotr Sri Krishna, S Kumar, Abhinav Lam, Winnie W Marciano, David Miller, Mitchell D Morse, Andrew T Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J Trame, Christine B van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Yeh, Andrew Zhou, Jiadong Hodgson, Keith O Wooley, John Elsliger, Marc-André Deacon, Ashley M Godzik, Adam Lesley, Scott A Wilson, Ian A |
author_sort | Das, Debanu |
collection | PubMed |
description | Sufu (Suppressor of Fused), a two-domain protein, plays a critical role in regulating Hedgehog signaling and is conserved from flies to humans. A few bacterial Sufu-like proteins have previously been identified based on sequence similarity to the N-terminal domain of eukaryotic Sufu proteins, but none have been structurally or biochemically characterized and their function in bacteria is unknown. We have determined the crystal structure of a more distantly related Sufu-like homolog, NGO1391 from Neisseria gonorrhoeae, at 1.4 Å resolution, which provides the first biophysical characterization of a bacterial Sufu-like protein. The structure revealed a striking similarity to the N-terminal domain of human Sufu (r.m.s.d. of 2.6 Å over 93% of the NGO1391 protein), despite an extremely low sequence identity of ∼15%. Subsequent sequence analysis revealed that NGO1391 defines a new subset of smaller, Sufu-like proteins that are present in ∼200 bacterial species and has resulted in expansion of the SUFU (PF05076) family in Pfam. |
format | Text |
id | pubmed-3005784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Wiley Subscription Services, Inc., A Wiley Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-30057842011-02-14 The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu Das, Debanu Finn, Robert D Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Bakolitsa, Constantina Cai, Xiaohui Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C Duan, Lian Ellrott, Kyle Farr, Carol L Feuerhelm, Julie Grant, Joanna C Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K Klock, Heath E Knuth, Mark W Kozbial, Piotr Sri Krishna, S Kumar, Abhinav Lam, Winnie W Marciano, David Miller, Mitchell D Morse, Andrew T Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J Trame, Christine B van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Yeh, Andrew Zhou, Jiadong Hodgson, Keith O Wooley, John Elsliger, Marc-André Deacon, Ashley M Godzik, Adam Lesley, Scott A Wilson, Ian A Protein Sci Article Sufu (Suppressor of Fused), a two-domain protein, plays a critical role in regulating Hedgehog signaling and is conserved from flies to humans. A few bacterial Sufu-like proteins have previously been identified based on sequence similarity to the N-terminal domain of eukaryotic Sufu proteins, but none have been structurally or biochemically characterized and their function in bacteria is unknown. We have determined the crystal structure of a more distantly related Sufu-like homolog, NGO1391 from Neisseria gonorrhoeae, at 1.4 Å resolution, which provides the first biophysical characterization of a bacterial Sufu-like protein. The structure revealed a striking similarity to the N-terminal domain of human Sufu (r.m.s.d. of 2.6 Å over 93% of the NGO1391 protein), despite an extremely low sequence identity of ∼15%. Subsequent sequence analysis revealed that NGO1391 defines a new subset of smaller, Sufu-like proteins that are present in ∼200 bacterial species and has resulted in expansion of the SUFU (PF05076) family in Pfam. Wiley Subscription Services, Inc., A Wiley Company 2010-11 2010-09-10 /pmc/articles/PMC3005784/ /pubmed/20836087 http://dx.doi.org/10.1002/pro.497 Text en Copyright © 2010 The Protein Society |
spellingShingle | Article Das, Debanu Finn, Robert D Abdubek, Polat Astakhova, Tamara Axelrod, Herbert L Bakolitsa, Constantina Cai, Xiaohui Carlton, Dennis Chen, Connie Chiu, Hsiu-Ju Chiu, Michelle Clayton, Thomas Deller, Marc C Duan, Lian Ellrott, Kyle Farr, Carol L Feuerhelm, Julie Grant, Joanna C Grzechnik, Anna Han, Gye Won Jaroszewski, Lukasz Jin, Kevin K Klock, Heath E Knuth, Mark W Kozbial, Piotr Sri Krishna, S Kumar, Abhinav Lam, Winnie W Marciano, David Miller, Mitchell D Morse, Andrew T Nigoghossian, Edward Nopakun, Amanda Okach, Linda Puckett, Christina Reyes, Ron Tien, Henry J Trame, Christine B van den Bedem, Henry Weekes, Dana Wooten, Tiffany Xu, Qingping Yeh, Andrew Zhou, Jiadong Hodgson, Keith O Wooley, John Elsliger, Marc-André Deacon, Ashley M Godzik, Adam Lesley, Scott A Wilson, Ian A The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu |
title | The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu |
title_full | The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu |
title_fullStr | The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu |
title_full_unstemmed | The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu |
title_short | The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu |
title_sort | crystal structure of a bacterial sufu-like protein defines a novel group of bacterial proteins that are similar to the n-terminal domain of human sufu |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005784/ https://www.ncbi.nlm.nih.gov/pubmed/20836087 http://dx.doi.org/10.1002/pro.497 |
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