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The Role of RUNX2 in Osteosarcoma Oncogenesis

Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for the RUNX2 “platform protein” in osteosarcoma oncogenesis. RU...

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Detalles Bibliográficos
Autores principales: Martin, J. W., Zielenska, M., Stein, G. S., van Wijnen, A. J., Squire, J. A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005824/
https://www.ncbi.nlm.nih.gov/pubmed/21197465
http://dx.doi.org/10.1155/2011/282745
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author Martin, J. W.
Zielenska, M.
Stein, G. S.
van Wijnen, A. J.
Squire, J. A.
author_facet Martin, J. W.
Zielenska, M.
Stein, G. S.
van Wijnen, A. J.
Squire, J. A.
author_sort Martin, J. W.
collection PubMed
description Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for the RUNX2 “platform protein” in osteosarcoma oncogenesis. RUNX proteins are DNA-binding transcription factors that regulate the expression of multiple genes involved in cellular differentiation and cell-cycle progression. RUNX2 is genetically essential for developing bone and osteoblast maturation. Studies of osteosarcoma tumours have revealed that the RUNX2 DNA copy number together with RNA and protein levels are highly elevated in osteosarcoma tumors. The protein is also important for metastatic bone disease of prostate and breast cancers, while RUNX2 may have both tumor suppressive and oncogenic roles in bone morphogenesis. This paper provides a synopsis of the current understanding of the functions of RUNX2 and its potential role in osteosarcoma and suggests directions for future study.
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spelling pubmed-30058242010-12-30 The Role of RUNX2 in Osteosarcoma Oncogenesis Martin, J. W. Zielenska, M. Stein, G. S. van Wijnen, A. J. Squire, J. A. Sarcoma Review Article Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for the RUNX2 “platform protein” in osteosarcoma oncogenesis. RUNX proteins are DNA-binding transcription factors that regulate the expression of multiple genes involved in cellular differentiation and cell-cycle progression. RUNX2 is genetically essential for developing bone and osteoblast maturation. Studies of osteosarcoma tumours have revealed that the RUNX2 DNA copy number together with RNA and protein levels are highly elevated in osteosarcoma tumors. The protein is also important for metastatic bone disease of prostate and breast cancers, while RUNX2 may have both tumor suppressive and oncogenic roles in bone morphogenesis. This paper provides a synopsis of the current understanding of the functions of RUNX2 and its potential role in osteosarcoma and suggests directions for future study. Hindawi Publishing Corporation 2011 2010-12-09 /pmc/articles/PMC3005824/ /pubmed/21197465 http://dx.doi.org/10.1155/2011/282745 Text en Copyright © 2011 J. W. Martin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Martin, J. W.
Zielenska, M.
Stein, G. S.
van Wijnen, A. J.
Squire, J. A.
The Role of RUNX2 in Osteosarcoma Oncogenesis
title The Role of RUNX2 in Osteosarcoma Oncogenesis
title_full The Role of RUNX2 in Osteosarcoma Oncogenesis
title_fullStr The Role of RUNX2 in Osteosarcoma Oncogenesis
title_full_unstemmed The Role of RUNX2 in Osteosarcoma Oncogenesis
title_short The Role of RUNX2 in Osteosarcoma Oncogenesis
title_sort role of runx2 in osteosarcoma oncogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005824/
https://www.ncbi.nlm.nih.gov/pubmed/21197465
http://dx.doi.org/10.1155/2011/282745
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