Cargando…
The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion
Reduced nitric oxide (NO) bioavailability and increased oxidative stress are major factors mediating ischemia/reperfusion (I/R) injury. Tetrahydrobiopterin (BH(4)) is an essential cofactor of endothelial NO synthase (eNOS) to produce NO, whereas dihydrobiopterin (BH(2)) can shift the eNOS product pr...
Autores principales: | Chen, Qian, Kim, Elizabeth Eun Jung, Elio, Katrina, Zambrano, Christopher, Krass, Samuel, Teng, Jane Chun-wen, Kay, Helen, Perkins, Kerry-Anne, Pershad, Sailesh, McGraw, Sloane, Emrich, Jeffrey, Adams, Jovan S., Young, Lindon H. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005837/ https://www.ncbi.nlm.nih.gov/pubmed/21188246 http://dx.doi.org/10.1155/2010/963914 |
Ejemplares similares
-
Autoxidation Kinetics of Tetrahydrobiopterin—Giving Quinonoid Dihydrobiopterin the Consideration It Deserves
por: Boulghobra, Ayoub, et al.
Publicado: (2023) -
Tetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of Rats
por: Ohashi, Akiko, et al.
Publicado: (2016) -
Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin
por: Maglione, Manuel, et al.
Publicado: (2012) -
0888. Administration of tetrahydrobiopterin (BH4) protects renal microcirculation after ischemia and reperfusion
por: Rahmania, L, et al.
Publicado: (2014) -
Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling
por: Schmidt, Kurt, et al.
Publicado: (2014)