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Targeting Angiogenesis in Childhood Sarcomas
Angiogenesis and vasculogenesis constitute two processes in the formation of new blood vessels and are essential for progression of solid tumors. Consequently, targeting angiogenesis, and to a lesser extent vasculogenesis, has become a major focus in cancer drug development. Angiogenesis inhibitors...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005857/ https://www.ncbi.nlm.nih.gov/pubmed/21197468 http://dx.doi.org/10.1155/2011/601514 |
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author | Bid, Hemant K. Houghton, Peter J. |
author_facet | Bid, Hemant K. Houghton, Peter J. |
author_sort | Bid, Hemant K. |
collection | PubMed |
description | Angiogenesis and vasculogenesis constitute two processes in the formation of new blood vessels and are essential for progression of solid tumors. Consequently, targeting angiogenesis, and to a lesser extent vasculogenesis, has become a major focus in cancer drug development. Angiogenesis inhibitors are now being tested in pediatric populations whereas inhibitors of vasculogenesis are in an earlier stage of development. Despite the initial enthusiasm for targeting angiogenesis for treatment of cancer, clinical trials have shown only incremental increases in survival, and agents have been largely cytostatic rather than inducing tumor regressions. Consequently, the role of such therapeutic approaches in the context of curative intent for childhood sarcomas is less clear. Here we review the literature on blood vessel formation in sarcomas with a focus on pediatric sarcomas and developments in targeting angiogenesis for treatment of these rare cancers. |
format | Text |
id | pubmed-3005857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30058572010-12-30 Targeting Angiogenesis in Childhood Sarcomas Bid, Hemant K. Houghton, Peter J. Sarcoma Review Article Angiogenesis and vasculogenesis constitute two processes in the formation of new blood vessels and are essential for progression of solid tumors. Consequently, targeting angiogenesis, and to a lesser extent vasculogenesis, has become a major focus in cancer drug development. Angiogenesis inhibitors are now being tested in pediatric populations whereas inhibitors of vasculogenesis are in an earlier stage of development. Despite the initial enthusiasm for targeting angiogenesis for treatment of cancer, clinical trials have shown only incremental increases in survival, and agents have been largely cytostatic rather than inducing tumor regressions. Consequently, the role of such therapeutic approaches in the context of curative intent for childhood sarcomas is less clear. Here we review the literature on blood vessel formation in sarcomas with a focus on pediatric sarcomas and developments in targeting angiogenesis for treatment of these rare cancers. Hindawi Publishing Corporation 2011 2010-12-09 /pmc/articles/PMC3005857/ /pubmed/21197468 http://dx.doi.org/10.1155/2011/601514 Text en Copyright © 2011 H. K. Bid and P. J. Houghton. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bid, Hemant K. Houghton, Peter J. Targeting Angiogenesis in Childhood Sarcomas |
title | Targeting Angiogenesis in Childhood Sarcomas |
title_full | Targeting Angiogenesis in Childhood Sarcomas |
title_fullStr | Targeting Angiogenesis in Childhood Sarcomas |
title_full_unstemmed | Targeting Angiogenesis in Childhood Sarcomas |
title_short | Targeting Angiogenesis in Childhood Sarcomas |
title_sort | targeting angiogenesis in childhood sarcomas |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005857/ https://www.ncbi.nlm.nih.gov/pubmed/21197468 http://dx.doi.org/10.1155/2011/601514 |
work_keys_str_mv | AT bidhemantk targetingangiogenesisinchildhoodsarcomas AT houghtonpeterj targetingangiogenesisinchildhoodsarcomas |