Targeting the OB-Folds of Replication Protein A with Small Molecules

Replication protein A (RPA) is the main eukaryotic single-strand (ss) DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs) that show in vitro inhibition of the RPA-DNA interaction. We present further characteriza...

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Detalles Bibliográficos
Autores principales: Anciano Granadillo, Victor J., Earley, Jennifer N., Shuck, Sarah C., Georgiadis, Millie M., Fitch, Richard W., Turchi, John J.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005895/
https://www.ncbi.nlm.nih.gov/pubmed/21188165
http://dx.doi.org/10.4061/2010/304035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005895/
https://www.ncbi.nlm.nih.gov/pubmed/21188165
http://dx.doi.org/10.4061/2010/304035

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