Cargando…

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

Germline mutations in the von Hippel–Lindau disease (VHL) and succinate dehydrogenase subunit B (SDHB) genes can cause inherited phaeochromocytoma and/or renal cell carcinoma (RCC). Dysregulation of the hypoxia-inducible factor (HIF) transcription factors has been linked to VHL and SDHB-related RCC;...

Descripción completa

Detalles Bibliográficos
Autores principales:	Astuti, Dewi, Ricketts, Christopher J, Chowdhury, Rasheduzzaman, McDonough, Michael A, Gentle, Dean, Kirby, Gail, Schlisio, Susanne, Kenchappa, Rajappa S, Carter, Bruce D, Kaelin, William G, Ratcliffe, Peter J, Schofield, Christopher J, Latif, Farida, Maher, Eamonn R
Formato:	Texto
Lenguaje:	English
Publicado:	Society for Endocrinology 2011
Materias:	Regular Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006001/ https://www.ncbi.nlm.nih.gov/pubmed/20959442 http://dx.doi.org/10.1677/ERC-10-0113

Ejemplares similares

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
por: Figg, William D., et al.
Publicado: (2021)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
por: Holt-Martyn, James P., et al.
Publicado: (2019)

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
por: Lippl, Kerstin, et al.
Publicado: (2018)

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors
por: Holt‐Martyn, James P., et al.
Publicado: (2019)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
por: Liu, Tongri, et al.
Publicado: (2021)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
por: Chowdhury, Rasheduzzaman, et al.
Publicado: (2016)

Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer
por: Rawluszko, Agnieszka A, et al.
Publicado: (2013)

Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases
por: Horita, Shoichiro, et al.
Publicado: (2015)

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
por: Yeh, Tzu-Lan, et al.
Publicado: (2017)

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2
por: Chowdhury, Rasheduzzaman, et al.
Publicado: (2020)

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
por: Bush, Jacob T., et al.
Publicado: (2019)

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
por: Chan, Mun Chiang, et al.
Publicado: (2015)

Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition
por: Place, Trenton L., et al.
Publicado: (2013)

Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins
por: Wong, Samantha J., et al.
Publicado: (2021)

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase
por: Longbotham, James E., et al.
Publicado: (2015)

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
por: Chan, Mun Chiang, et al.
Publicado: (2016)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
por: Cockman, Matthew E, et al.
Publicado: (2019)

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
por: Abboud, Martine I., et al.
Publicado: (2018)

Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells
por: Högel, Heidi, et al.
Publicado: (2011)

Molecular Characterization and Response of Prolyl Hydroxylase Domain (PHD) Genes to Hypoxia Stress in Hypophthalmichthys molitrix
por: Li, Xiaohui, et al.
Publicado: (2022)

Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression
por: Rohrbach, Susanne, et al.
Publicado: (2008)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor
por: Kiriakidis, Serafim, et al.
Publicado: (2017)

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
por: Zheng, Xingnan, et al.
Publicado: (2014)

Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27
por: Högel, Heidi, et al.
Publicado: (2015)

Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Regulates Chondrocyte Differentiation and Secondary Ossification in Mice
por: Cheng, Shaohong, et al.
Publicado: (2016)

mRNA overexpression of prolyl hydroxylase PHD3 is inversely related to nuclear grade in renal cell carcinoma
por: Kampantais, Spyridon, et al.
Publicado: (2020)

Evaluation of a functional epigenetic approach to identify promoter region methylation in phaeochromocytoma and neuroblastoma
por: Margetts, Caroline D E, et al.
Publicado: (2008)

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
por: Thinnes, Cyrille C., et al.
Publicado: (2019)

Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma
por: Astuti, D, et al.
Publicado: (2004)

Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans
por: Minervini, Giovanni, et al.
Publicado: (2016)

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
por: Miikkulainen, Petra, et al.
Publicado: (2017)

Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (Phd1) Gene Expressed in Chondrocytes
por: Xing, Weirong, et al.
Publicado: (2022)

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23
por: Noonan, Megan L., et al.
Publicado: (2023)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
por: Sadiku, Pranvera, et al.
Publicado: (2017)

A human protein hydroxylase that accepts D-residues
por: Choi, Hwanho, et al.
Publicado: (2020)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
por: Singh, Ayesha, et al.
Publicado: (2020)

Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury
por: Fang, Yi, et al.
Publicado: (2016)

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia
por: Jatho, Aline, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6parmhs8m6taj4nju9s4teasjk