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Metformin for aging and cancer prevention
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the cor...
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Formato: | Texto |
Lenguaje: | English |
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Impact Journals LLC
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006019/ https://www.ncbi.nlm.nih.gov/pubmed/21084729 |
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author | Anisimov, Vladimir N. |
author_facet | Anisimov, Vladimir N. |
author_sort | Anisimov, Vladimir N. |
collection | PubMed |
description | Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases life span in nematodes, fruit flies and mice. It is possible that the life-prolonging effect of caloric restriction is due to decreasing IGF-1 levels. Evidence has emerged that antidiabetic drugs are promising candidates for both life span extension and prevention of cancer. Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore metformin seems to decrease cancer risk in diabetic patients. |
format | Text |
id | pubmed-3006019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-30060192010-12-22 Metformin for aging and cancer prevention Anisimov, Vladimir N. Aging (Albany NY) Review Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors in aging. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases life span in nematodes, fruit flies and mice. It is possible that the life-prolonging effect of caloric restriction is due to decreasing IGF-1 levels. Evidence has emerged that antidiabetic drugs are promising candidates for both life span extension and prevention of cancer. Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore metformin seems to decrease cancer risk in diabetic patients. Impact Journals LLC 2010-11-11 /pmc/articles/PMC3006019/ /pubmed/21084729 Text en Copyright: © 2010 Anisimov http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Review Anisimov, Vladimir N. Metformin for aging and cancer prevention |
title | Metformin for aging and cancer prevention |
title_full | Metformin for aging and cancer prevention |
title_fullStr | Metformin for aging and cancer prevention |
title_full_unstemmed | Metformin for aging and cancer prevention |
title_short | Metformin for aging and cancer prevention |
title_sort | metformin for aging and cancer prevention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006019/ https://www.ncbi.nlm.nih.gov/pubmed/21084729 |
work_keys_str_mv | AT anisimovvladimirn metforminforagingandcancerprevention |