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Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates
The CagA protein of Helicobacter pylori interacts with numerous cellular factors, and is associated with increased virulence and risk of gastric carcinoma. We present here the co-crystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrat...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006182/ https://www.ncbi.nlm.nih.gov/pubmed/19966800 http://dx.doi.org/10.1038/nsmb.1705 |