A Novel Statistical Algorithm for Gene Expression Analysis Helps Differentiate Pregnane X Receptor-Dependent and Independent Mechanisms of Toxicity

Genome-wide gene expression profiling has become standard for assessing potential liabilities as well as for elucidating mechanisms of toxicity of drug candidates under development. Analysis of microarray data is often challenging due to the lack of a statistical model that is amenable to biological...

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Detalles Bibliográficos
Autores principales: Mongan, M. Ann, Dunn, Robert T., Vonderfecht, Steven, Everds, Nancy, Chen, Guang, Su, Cheng, Higgins-Garn, Marnie, Chen, Yuan, Afshari, Cynthia A., Williamson, Toni L., Carlock, Linda, DiPalma, Christopher, Moss, Suzanne, Bussiere, Jeanine, Qualls, Charles, He, Yudong D., Hamadeh, Hisham K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006344/
https://www.ncbi.nlm.nih.gov/pubmed/21203578
http://dx.doi.org/10.1371/journal.pone.0015595

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