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An animal paired crossover ePTFE arteriovenous graft model

PURPOSE: Previously, we developed a porcine model for Arterio Venous Graft (AVG) failure to allow assessment of new access strategies. This model was limited concerning graft length. In the present technical report, we describe a modification of our model allowing the assessment of long AVGs. TECHNI...

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Autores principales: Jahrome, Abdelkarime K, Hoefer, Imo, Moll, Frans L, Houston, Graeme J, Stonebridge, Peter A, Blankestijn, Peter J, de Borst, Gert J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006397/
https://www.ncbi.nlm.nih.gov/pubmed/21110903
http://dx.doi.org/10.1186/1750-1164-4-7
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author Jahrome, Abdelkarime K
Hoefer, Imo
Moll, Frans L
Houston, Graeme J
Stonebridge, Peter A
Blankestijn, Peter J
de Borst, Gert J
author_facet Jahrome, Abdelkarime K
Hoefer, Imo
Moll, Frans L
Houston, Graeme J
Stonebridge, Peter A
Blankestijn, Peter J
de Borst, Gert J
author_sort Jahrome, Abdelkarime K
collection PubMed
description PURPOSE: Previously, we developed a porcine model for Arterio Venous Graft (AVG) failure to allow assessment of new access strategies. This model was limited concerning graft length. In the present technical report, we describe a modification of our model allowing the assessment of long AVGs. TECHNIQUE: In 4 pigs, AVGs of 15 cm length were created bilaterally in a cross-over fashion between the carotid artery and the contralateral jugular vein. Two days (2 pigs) and two weeks (2 pigs) after AV shunting, graft patency was evaluated by angiography, showing all four grafts to be patent, with no sign of angiographic or macroscopic narrowing at the anastomoses sites. CONCLUSIONS: In this modified pig AVG failure model, implantation of a bilateral cross-over long AVG is a feasible approach. The present model offers a suitable tool to study local interventions or compare various long graft designs aimed at improvement of AVG patency.
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spelling pubmed-30063972010-12-22 An animal paired crossover ePTFE arteriovenous graft model Jahrome, Abdelkarime K Hoefer, Imo Moll, Frans L Houston, Graeme J Stonebridge, Peter A Blankestijn, Peter J de Borst, Gert J Ann Surg Innov Res Research Article PURPOSE: Previously, we developed a porcine model for Arterio Venous Graft (AVG) failure to allow assessment of new access strategies. This model was limited concerning graft length. In the present technical report, we describe a modification of our model allowing the assessment of long AVGs. TECHNIQUE: In 4 pigs, AVGs of 15 cm length were created bilaterally in a cross-over fashion between the carotid artery and the contralateral jugular vein. Two days (2 pigs) and two weeks (2 pigs) after AV shunting, graft patency was evaluated by angiography, showing all four grafts to be patent, with no sign of angiographic or macroscopic narrowing at the anastomoses sites. CONCLUSIONS: In this modified pig AVG failure model, implantation of a bilateral cross-over long AVG is a feasible approach. The present model offers a suitable tool to study local interventions or compare various long graft designs aimed at improvement of AVG patency. BioMed Central 2010-11-29 /pmc/articles/PMC3006397/ /pubmed/21110903 http://dx.doi.org/10.1186/1750-1164-4-7 Text en Copyright ©2010 Jahrome et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jahrome, Abdelkarime K
Hoefer, Imo
Moll, Frans L
Houston, Graeme J
Stonebridge, Peter A
Blankestijn, Peter J
de Borst, Gert J
An animal paired crossover ePTFE arteriovenous graft model
title An animal paired crossover ePTFE arteriovenous graft model
title_full An animal paired crossover ePTFE arteriovenous graft model
title_fullStr An animal paired crossover ePTFE arteriovenous graft model
title_full_unstemmed An animal paired crossover ePTFE arteriovenous graft model
title_short An animal paired crossover ePTFE arteriovenous graft model
title_sort animal paired crossover eptfe arteriovenous graft model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006397/
https://www.ncbi.nlm.nih.gov/pubmed/21110903
http://dx.doi.org/10.1186/1750-1164-4-7
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