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N-[3-Chloro-4-(3-fluoro­benz­yloxy)phen­yl]-6-iodo­quinazolin-4-amine

In the title mol­ecule, C(21)H(14)ClFIN(3)O, the bicyclic ring system has a twisted conformation; the two fused rings form a dihedral angle of 4.5 (1)°. The dihedral angles between the fused ring system and the benzene rings are 27.3 (6) and 5.3 (5)° while the dihedral angle between the benzene ring...

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Detalles Bibliográficos
Autores principales: Cai, Zhi-Qiang, Liu, Jing-Guo, Zhou, Wei-Wei, Li, Yi-Liang
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006786/
https://www.ncbi.nlm.nih.gov/pubmed/21588019
http://dx.doi.org/10.1107/S1600536810021847
Descripción
Sumario:In the title mol­ecule, C(21)H(14)ClFIN(3)O, the bicyclic ring system has a twisted conformation; the two fused rings form a dihedral angle of 4.5 (1)°. The dihedral angles between the fused ring system and the benzene rings are 27.3 (6) and 5.3 (5)° while the dihedral angle between the benzene rings is 22.0 (5)°. In the crystal structure, weak inter­molecular N—H⋯N hydrogen bonds link the mol­ecules into chains propagating in [100]. A short inter­molecular distance of 3.806 (3) Å between the centroids of the fluorobenzene and iodobenzene rings suggests the existence of π–π stacking inter­actions.