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Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
Biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is linked to the development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as well as other abnormalities. The VHL gene product, pVHL, is part of an E3 ubiquitin ligase complex that targets the α su...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC300692/ https://www.ncbi.nlm.nih.gov/pubmed/14691554 http://dx.doi.org/10.1371/journal.pbio.0000083 |