rac-Ethyl 4-hy­droxy-6-(2-hy­droxy­phen­yl)-2-oxo-4-(trifluoro­methyl)per­hydro­pyrimidine-5-carboxyl­ate

In the title compound, C(14)H(15)F(3)N(2)O(5), prepared by reaction of 2-hy­droxy­benzaldehyde, ethyl 4,4,4-trifluoro-3-oxobutano­ate and urea, the tetra­pyrimidine ring adopts a half-chair conformation. The crystal structure is stabilized by five inter­molecular hydrogen bonds, three O—H⋯O and two...

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Detalles Bibliográficos
Autores principales: Song, Xiao-Ping, Li, Gong-Chun, Zhu, Feng-Xiang, Wu, Chang-Zeng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006922/
https://www.ncbi.nlm.nih.gov/pubmed/21587879
http://dx.doi.org/10.1107/S1600536810021355
Descripción
Sumario:In the title compound, C(14)H(15)F(3)N(2)O(5), prepared by reaction of 2-hy­droxy­benzaldehyde, ethyl 4,4,4-trifluoro-3-oxobutano­ate and urea, the tetra­pyrimidine ring adopts a half-chair conformation. The crystal structure is stabilized by five inter­molecular hydrogen bonds, three O—H⋯O and two N—H⋯O, giving cyclic dimers (through three hydrogen bonds) which are further extended into a two-dimensional network.

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