Somatic p16(INK4a) loss accelerates melanomagenesis

Loss of p16(INK4a)–RB and ARF–p53 tumor suppressor pathways, as well as activation of RAS–RAF signaling, is seen in a majority of human melanomas. Although heterozygous germline mutations of p16(INK4a) are associated with familial melanoma, most melanomas result from somatic genetic events: often p1...

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Detalles Bibliográficos
Autores principales: Monahan, K B, Rozenberg, G I, Krishnamurthy, J, Johnson, S M, Liu, W, Bradford, M K, Horner, J, DePinho, R A, Sharpless, N E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007178/
https://www.ncbi.nlm.nih.gov/pubmed/20697345
http://dx.doi.org/10.1038/onc.2010.314

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