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Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base
Cefadroxil drug loaded biopolymeric films of chitosan-furfural schiff base were prepared by reacting chitosan with furfural in presence of acetic acid and perchloric acid respectively for the external use. Prepared films were evaluated for their strength, swelling index, thickness, drug content, uni...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Österreichische Apotheker-Verlagsgesellschaft
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007606/ https://www.ncbi.nlm.nih.gov/pubmed/21179325 http://dx.doi.org/10.3797/scipharm.0912-20 |
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author | Dixit, Ritu B. Uplana, Rahul A. Patel, Vishnu A. Dixit, Bharat C. Patel, Tarosh S. |
author_facet | Dixit, Ritu B. Uplana, Rahul A. Patel, Vishnu A. Dixit, Bharat C. Patel, Tarosh S. |
author_sort | Dixit, Ritu B. |
collection | PubMed |
description | Cefadroxil drug loaded biopolymeric films of chitosan-furfural schiff base were prepared by reacting chitosan with furfural in presence of acetic acid and perchloric acid respectively for the external use. Prepared films were evaluated for their strength, swelling index, thickness, drug content, uniformity, tensile strength, percent elongation, FTIR spectral analysis and SEM. The results of in vitro diffusion studies revealed that the films exhibited enhanced drug diffusion as compared to the films prepared using untreated chitosan. The films also demonstrated good to moderate antibacterial activities against selective gram positive and gram negative bacteria. |
format | Text |
id | pubmed-3007606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Österreichische Apotheker-Verlagsgesellschaft |
record_format | MEDLINE/PubMed |
spelling | pubmed-30076062010-12-22 Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base Dixit, Ritu B. Uplana, Rahul A. Patel, Vishnu A. Dixit, Bharat C. Patel, Tarosh S. Sci Pharm Original Papers Cefadroxil drug loaded biopolymeric films of chitosan-furfural schiff base were prepared by reacting chitosan with furfural in presence of acetic acid and perchloric acid respectively for the external use. Prepared films were evaluated for their strength, swelling index, thickness, drug content, uniformity, tensile strength, percent elongation, FTIR spectral analysis and SEM. The results of in vitro diffusion studies revealed that the films exhibited enhanced drug diffusion as compared to the films prepared using untreated chitosan. The films also demonstrated good to moderate antibacterial activities against selective gram positive and gram negative bacteria. Österreichische Apotheker-Verlagsgesellschaft 2010 2010-09-26 /pmc/articles/PMC3007606/ /pubmed/21179325 http://dx.doi.org/10.3797/scipharm.0912-20 Text en © Dixit et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Papers Dixit, Ritu B. Uplana, Rahul A. Patel, Vishnu A. Dixit, Bharat C. Patel, Tarosh S. Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base |
title | Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base |
title_full | Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base |
title_fullStr | Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base |
title_full_unstemmed | Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base |
title_short | Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base |
title_sort | development and evaluation of cefadroxil drug loaded biopolymeric films based on chitosan-furfural schiff base |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007606/ https://www.ncbi.nlm.nih.gov/pubmed/21179325 http://dx.doi.org/10.3797/scipharm.0912-20 |
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