Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones

3,4-Epoxy-2-dodecanone, a major component in the preorbital gland of the African grey duiker (Sylvicapra grimmia), showed antimicrobial activity in preliminary tests. The C(11) to C(17) homologues of this compound were prepared and their activity against several pathogenic dermal bacteria and fungi...

Descripción completa

Detalles Bibliográficos
Autor principal: Wood, William F.
Formato: Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2010
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007617/
https://www.ncbi.nlm.nih.gov/pubmed/21179314
http://dx.doi.org/10.3797/scipharm.1009-02
_version_ 1782194397815767040
author Wood, William F.
author_facet Wood, William F.
author_sort Wood, William F.
collection PubMed
description 3,4-Epoxy-2-dodecanone, a major component in the preorbital gland of the African grey duiker (Sylvicapra grimmia), showed antimicrobial activity in preliminary tests. The C(11) to C(17) homologues of this compound were prepared and their activity against several pathogenic dermal bacteria and fungi was tested. 3,4-Epoxy-2-dodecanone and 3,4-epoxy-2-tridecanone inhibited the growth of Trichophyton mentagrophytes at 25 μg/mL. Moderate inhibition of the growth of the bacteria Propionibacterium acnes and the lipophilic yeast, Pityrosporum ovale, was seen for several of the homologues.
format Text
id pubmed-3007617
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Österreichische Apotheker-Verlagsgesellschaft
record_format MEDLINE/PubMed
spelling pubmed-30076172010-12-22 Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones Wood, William F. Sci Pharm Original Papers 3,4-Epoxy-2-dodecanone, a major component in the preorbital gland of the African grey duiker (Sylvicapra grimmia), showed antimicrobial activity in preliminary tests. The C(11) to C(17) homologues of this compound were prepared and their activity against several pathogenic dermal bacteria and fungi was tested. 3,4-Epoxy-2-dodecanone and 3,4-epoxy-2-tridecanone inhibited the growth of Trichophyton mentagrophytes at 25 μg/mL. Moderate inhibition of the growth of the bacteria Propionibacterium acnes and the lipophilic yeast, Pityrosporum ovale, was seen for several of the homologues. Österreichische Apotheker-Verlagsgesellschaft 2010 2010-10-09 /pmc/articles/PMC3007617/ /pubmed/21179314 http://dx.doi.org/10.3797/scipharm.1009-02 Text en © Wood; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
Wood, William F.
Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones
title Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones
title_full Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones
title_fullStr Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones
title_full_unstemmed Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones
title_short Synthesis and Antimicrobial Activity of Long-Chain 3,4-Epoxy-2-alkanones
title_sort synthesis and antimicrobial activity of long-chain 3,4-epoxy-2-alkanones
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007617/
https://www.ncbi.nlm.nih.gov/pubmed/21179314
http://dx.doi.org/10.3797/scipharm.1009-02
work_keys_str_mv AT woodwilliamf synthesisandantimicrobialactivityoflongchain34epoxy2alkanones

Ejemplares similares