Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer

The microtubule-stabilizing drug paclitaxel has activity in relapsed ovarian cancer. dl922-947, an oncolytic adenovirus with a 24-bp deletion in E1A CR2, replicates selectively within and lyses cells with a dysregulated Rb pathway and has efficacy in ovarian cancer. In the aggressive A2780CP xenogra...

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Detalles Bibliográficos
Autores principales: Ingemarsdotter, C K, Baird, S K, Connell, C M, Öberg, D, Halldén, G, McNeish, I A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007619/
https://www.ncbi.nlm.nih.gov/pubmed/20729921
http://dx.doi.org/10.1038/onc.2010.335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007619/
https://www.ncbi.nlm.nih.gov/pubmed/20729921
http://dx.doi.org/10.1038/onc.2010.335

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