Nicotinamide-independent asymmetric bioreduction of C[bond, double bond]C-bonds via disproportionation of enones catalyzed by enoate reductases

The asymmetric bioreduction of activated C[bond, double bond]C-bonds catalyzed by a single flavoprotein was achieved via direct hydrogen transfer from a sacrificial 2-enone or 1,4-dione as hydrogen donor without requirement of a nicotinamide cofactor. Due to its simplicity, this system has clear adv...

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Detalles Bibliográficos
Autores principales: Stueckler, Clemens, Reiter, Tamara C., Baudendistel, Nina, Faber, Kurt
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007678/
https://www.ncbi.nlm.nih.gov/pubmed/21270958
http://dx.doi.org/10.1016/j.tet.2009.11.065
Descripción
Sumario:The asymmetric bioreduction of activated C[bond, double bond]C-bonds catalyzed by a single flavoprotein was achieved via direct hydrogen transfer from a sacrificial 2-enone or 1,4-dione as hydrogen donor without requirement of a nicotinamide cofactor. Due to its simplicity, this system has clear advantages over conventional FAD-recycling systems.

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