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1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one
In the title indoline compound, C(19)H(14)N(2)O(3)S, the pyrrolidine ring adopts an envelope conformation with the four-connected (spiro) C atom as the flap [displacement = 0.148 (3) Å]. The mean plane formed through the indoline unit is inclined at dihedral angles of 89.92 (16) and 59.54 (12)° with...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007916/ https://www.ncbi.nlm.nih.gov/pubmed/21588619 http://dx.doi.org/10.1107/S1600536810031016 |
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author | Fun, Hoong-Kun Goh, Jia Hao Liu, Yang Zhang, Yan |
author_facet | Fun, Hoong-Kun Goh, Jia Hao Liu, Yang Zhang, Yan |
author_sort | Fun, Hoong-Kun |
collection | PubMed |
description | In the title indoline compound, C(19)H(14)N(2)O(3)S, the pyrrolidine ring adopts an envelope conformation with the four-connected (spiro) C atom as the flap [displacement = 0.148 (3) Å]. The mean plane formed through the indoline unit is inclined at dihedral angles of 89.92 (16) and 59.54 (12)° with the thiazole and phenyl rings, respectively; the dihedral angle between the latter rings is 9.55 (14)°. In the crystal, pairs of intermolecular C—H⋯O hydrogen bonds link neighbouring molecules into inversion dimers, producing R (2) (2)(6) hydrogen-bond ring motifs. Weak intermolecular C—H⋯π as well as π–π interactions [centroid–centroid distance = 3.4041 (15) Å] further consolidate the crystal structure. |
format | Text |
id | pubmed-3007916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-30079162010-12-30 1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one Fun, Hoong-Kun Goh, Jia Hao Liu, Yang Zhang, Yan Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title indoline compound, C(19)H(14)N(2)O(3)S, the pyrrolidine ring adopts an envelope conformation with the four-connected (spiro) C atom as the flap [displacement = 0.148 (3) Å]. The mean plane formed through the indoline unit is inclined at dihedral angles of 89.92 (16) and 59.54 (12)° with the thiazole and phenyl rings, respectively; the dihedral angle between the latter rings is 9.55 (14)°. In the crystal, pairs of intermolecular C—H⋯O hydrogen bonds link neighbouring molecules into inversion dimers, producing R (2) (2)(6) hydrogen-bond ring motifs. Weak intermolecular C—H⋯π as well as π–π interactions [centroid–centroid distance = 3.4041 (15) Å] further consolidate the crystal structure. International Union of Crystallography 2010-08-11 /pmc/articles/PMC3007916/ /pubmed/21588619 http://dx.doi.org/10.1107/S1600536810031016 Text en © Fun et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Fun, Hoong-Kun Goh, Jia Hao Liu, Yang Zhang, Yan 1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one |
title | 1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one |
title_full | 1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one |
title_fullStr | 1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one |
title_full_unstemmed | 1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one |
title_short | 1′-Acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one |
title_sort | 1′-acetyl-3-phenyl-6-oxa-4-thia-2-azaspiro[bicyclo[3.2.0]hept-2-ene-7,3′-indolin]-2′-one |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007916/ https://www.ncbi.nlm.nih.gov/pubmed/21588619 http://dx.doi.org/10.1107/S1600536810031016 |
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