N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea

The title compound, C(11)H(10)N(4)O(4)S, is a derivative of N-(4-meth­oxy­benz­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea (AR-A014418), a known glycogen synthase kinase 3β (GSK-3β) inhibitor. All non-H atoms in the mol­ecule are essentially coplanar, with an r.m.s. deviation of 0.045 Å and a maximum dev...

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Detalles Bibliográficos
Autores principales: Lough, Alan J., Hicks, Justin W., Valliant, John F., Wilson, Alan A., Vasdev, Neil
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008116/
https://www.ncbi.nlm.nih.gov/pubmed/21588684
http://dx.doi.org/10.1107/S1600536810032186
Descripción
Sumario:The title compound, C(11)H(10)N(4)O(4)S, is a derivative of N-(4-meth­oxy­benz­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea (AR-A014418), a known glycogen synthase kinase 3β (GSK-3β) inhibitor. All non-H atoms in the mol­ecule are essentially coplanar, with an r.m.s. deviation of 0.045 Å and a maximum deviation of 0.115 (2) Å for the carbonyl O atom. In the crystal structure, mol­ecules are linked via N—H⋯O hydrogen bonds into one-dimensional chains along [101].

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