N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea

The title compound, C(11)H(10)N(4)O(4)S, is a derivative of N-(4-meth­oxy­benz­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea (AR-A014418), a known glycogen synthase kinase 3β (GSK-3β) inhibitor. All non-H atoms in the mol­ecule are essentially coplanar, with an r.m.s. deviation of 0.045 Å and a maximum dev...

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Detalles Bibliográficos
Autores principales: Lough, Alan J., Hicks, Justin W., Valliant, John F., Wilson, Alan A., Vasdev, Neil
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008116/
https://www.ncbi.nlm.nih.gov/pubmed/21588684
http://dx.doi.org/10.1107/S1600536810032186
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author Lough, Alan J.
Hicks, Justin W.
Valliant, John F.
Wilson, Alan A.
Vasdev, Neil
author_facet Lough, Alan J.
Hicks, Justin W.
Valliant, John F.
Wilson, Alan A.
Vasdev, Neil
author_sort Lough, Alan J.
collection PubMed
description The title compound, C(11)H(10)N(4)O(4)S, is a derivative of N-(4-meth­oxy­benz­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea (AR-A014418), a known glycogen synthase kinase 3β (GSK-3β) inhibitor. All non-H atoms in the mol­ecule are essentially coplanar, with an r.m.s. deviation of 0.045 Å and a maximum deviation of 0.115 (2) Å for the carbonyl O atom. In the crystal structure, mol­ecules are linked via N—H⋯O hydrogen bonds into one-dimensional chains along [101].
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spelling pubmed-30081162010-12-30 N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea Lough, Alan J. Hicks, Justin W. Valliant, John F. Wilson, Alan A. Vasdev, Neil Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(11)H(10)N(4)O(4)S, is a derivative of N-(4-meth­oxy­benz­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea (AR-A014418), a known glycogen synthase kinase 3β (GSK-3β) inhibitor. All non-H atoms in the mol­ecule are essentially coplanar, with an r.m.s. deviation of 0.045 Å and a maximum deviation of 0.115 (2) Å for the carbonyl O atom. In the crystal structure, mol­ecules are linked via N—H⋯O hydrogen bonds into one-dimensional chains along [101]. International Union of Crystallography 2010-08-18 /pmc/articles/PMC3008116/ /pubmed/21588684 http://dx.doi.org/10.1107/S1600536810032186 Text en © Lough et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Lough, Alan J.
Hicks, Justin W.
Valliant, John F.
Wilson, Alan A.
Vasdev, Neil
N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea
title N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea
title_full N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea
title_fullStr N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea
title_full_unstemmed N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea
title_short N-(4-Meth­oxy­phen­yl)-N′-(5-nitro-1,3-thia­zol-2-yl)urea
title_sort n-(4-meth­oxy­phen­yl)-n′-(5-nitro-1,3-thia­zol-2-yl)urea
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008116/
https://www.ncbi.nlm.nih.gov/pubmed/21588684
http://dx.doi.org/10.1107/S1600536810032186
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