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BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma

BACKGROUND: Although gene expression profile of multiple myeloma (MM) patients shows a wide range of Bik/Nbk expression, varying from absent to high, its regulation and function in myeloma cells is poorly understood. Thus, we addressed these questions in MM. METHODS: Human myeloma cell lines (HMCLs)...

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Detalles Bibliográficos
Autores principales:	Bodet, L, Ménoret, E, Descamps, G, Pellat-Deceunynck, C, Bataille, R, Le Gouill, S, Moreau, P, Amiot, M, Gomez-Bougie, P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008608/ https://www.ncbi.nlm.nih.gov/pubmed/21063407 http://dx.doi.org/10.1038/sj.bjc.6605981

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