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Maltose-Binding Protein Enhances Secretion of Recombinant Human Granzyme B Accompanied by In Vivo Processing of a Precursor MBP Fusion Protein

BACKGROUND: The apoptosis-inducing serine protease granzyme B (GrB) is an important factor contributing to lysis of target cells by cytotoxic lymphocytes. Expression of enzymatically active GrB in recombinant form is a prerequisite for functional analysis and application of GrB for therapeutic purpo...

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Detalles Bibliográficos
Autores principales:	Dälken, Benjamin, Jabulowsky, Robert A., Oberoi, Pranav, Benhar, Itai, Wels, Winfried S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008669/ https://www.ncbi.nlm.nih.gov/pubmed/21203542 http://dx.doi.org/10.1371/journal.pone.0014404

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