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Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts
BACKGROUND: During scleroderma (SSc) pathogenesis, fibroblasts acquire an activated phenotype characterized by enhanced production of extracellular matrix (ECM) and constitutive activation of several major signaling pathways including extracellular signal-related kinase (ERK1/2). Several studies hav...
Autores principales: | Samuel, Glady H, Bujor, Andreea M, Nakerakanti, Sashidhar S, Hant, Faye N, Trojanowska, Maria |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008687/ https://www.ncbi.nlm.nih.gov/pubmed/21134273 http://dx.doi.org/10.1186/1755-1536-3-25 |
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