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High-dose steroid therapy for idiopathic optic perineuritis: a case series

INTRODUCTION: It has been reported that the prognosis of optic perineuritis may be poor when initiation of treatment is delayed. Here we report the successful treatment of three patients with idiopathic optic perineuritis, including two in whom initiation of therapy was delayed. CASE PRESENTATION: T...

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Detalles Bibliográficos
Autores principales: Tatsugawa, Maria, Noma, Hidetaka, Mimura, Tatsuya, Funatsu, Hideharu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008697/
https://www.ncbi.nlm.nih.gov/pubmed/21143958
http://dx.doi.org/10.1186/1752-1947-4-404
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author Tatsugawa, Maria
Noma, Hidetaka
Mimura, Tatsuya
Funatsu, Hideharu
author_facet Tatsugawa, Maria
Noma, Hidetaka
Mimura, Tatsuya
Funatsu, Hideharu
author_sort Tatsugawa, Maria
collection PubMed
description INTRODUCTION: It has been reported that the prognosis of optic perineuritis may be poor when initiation of treatment is delayed. Here we report the successful treatment of three patients with idiopathic optic perineuritis, including two in whom initiation of therapy was delayed. CASE PRESENTATION: Three Japanese patients (two women aged 73 and 66 years, and one man aged 27 years) presented with loss of vision (for five months, several months, and two months respectively) and pain on eye movement in the third case only, and were diagnosed as having idiopathic optic perineuritis. Fat-suppressed T2-weighted magnetic resonance images showed high signal intensity areas around the affected optic nerves, suggesting the presence of optic perineuritis. Two patients received steroid pulse therapy and the third was given high-dose steroid therapy. The visual acuity improved in all three cases. CONCLUSION: High-dose steroid therapy may be effective for idiopathic perineuritis in patients without optic nerve atrophy, even if initial treatment (including moderate-dose steroids) has failed.
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spelling pubmed-30086972010-12-23 High-dose steroid therapy for idiopathic optic perineuritis: a case series Tatsugawa, Maria Noma, Hidetaka Mimura, Tatsuya Funatsu, Hideharu J Med Case Reports Case Report INTRODUCTION: It has been reported that the prognosis of optic perineuritis may be poor when initiation of treatment is delayed. Here we report the successful treatment of three patients with idiopathic optic perineuritis, including two in whom initiation of therapy was delayed. CASE PRESENTATION: Three Japanese patients (two women aged 73 and 66 years, and one man aged 27 years) presented with loss of vision (for five months, several months, and two months respectively) and pain on eye movement in the third case only, and were diagnosed as having idiopathic optic perineuritis. Fat-suppressed T2-weighted magnetic resonance images showed high signal intensity areas around the affected optic nerves, suggesting the presence of optic perineuritis. Two patients received steroid pulse therapy and the third was given high-dose steroid therapy. The visual acuity improved in all three cases. CONCLUSION: High-dose steroid therapy may be effective for idiopathic perineuritis in patients without optic nerve atrophy, even if initial treatment (including moderate-dose steroids) has failed. BioMed Central 2010-12-10 /pmc/articles/PMC3008697/ /pubmed/21143958 http://dx.doi.org/10.1186/1752-1947-4-404 Text en Copyright ©2010 Tatsugawa et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tatsugawa, Maria
Noma, Hidetaka
Mimura, Tatsuya
Funatsu, Hideharu
High-dose steroid therapy for idiopathic optic perineuritis: a case series
title High-dose steroid therapy for idiopathic optic perineuritis: a case series
title_full High-dose steroid therapy for idiopathic optic perineuritis: a case series
title_fullStr High-dose steroid therapy for idiopathic optic perineuritis: a case series
title_full_unstemmed High-dose steroid therapy for idiopathic optic perineuritis: a case series
title_short High-dose steroid therapy for idiopathic optic perineuritis: a case series
title_sort high-dose steroid therapy for idiopathic optic perineuritis: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008697/
https://www.ncbi.nlm.nih.gov/pubmed/21143958
http://dx.doi.org/10.1186/1752-1947-4-404
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