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RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients

RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it...

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Autores principales: Chano, Tokuhiro, Ikebuchi, Kaichiro, Tomita, Yasuhiko, Jin, Yufen, Inaji, Hideo, Ishitobi, Makoto, Teramoto, Koji, Ochi, Yasuko, Tameno, Hitosuke, Nishimura, Ichiro, Minami, Kahori, Inoue, Hirokazu, Isono, Takahiro, Saitoh, Masao, Shimada, Taketoshi, Hisa, Yasuo, Okabe, Hidetoshi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008740/
https://www.ncbi.nlm.nih.gov/pubmed/21203526
http://dx.doi.org/10.1371/journal.pone.0015737
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author Chano, Tokuhiro
Ikebuchi, Kaichiro
Tomita, Yasuhiko
Jin, Yufen
Inaji, Hideo
Ishitobi, Makoto
Teramoto, Koji
Ochi, Yasuko
Tameno, Hitosuke
Nishimura, Ichiro
Minami, Kahori
Inoue, Hirokazu
Isono, Takahiro
Saitoh, Masao
Shimada, Taketoshi
Hisa, Yasuo
Okabe, Hidetoshi
author_facet Chano, Tokuhiro
Ikebuchi, Kaichiro
Tomita, Yasuhiko
Jin, Yufen
Inaji, Hideo
Ishitobi, Makoto
Teramoto, Koji
Ochi, Yasuko
Tameno, Hitosuke
Nishimura, Ichiro
Minami, Kahori
Inoue, Hirokazu
Isono, Takahiro
Saitoh, Masao
Shimada, Taketoshi
Hisa, Yasuo
Okabe, Hidetoshi
author_sort Chano, Tokuhiro
collection PubMed
description RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval = 1.566–9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination.
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spelling pubmed-30087402011-01-03 RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients Chano, Tokuhiro Ikebuchi, Kaichiro Tomita, Yasuhiko Jin, Yufen Inaji, Hideo Ishitobi, Makoto Teramoto, Koji Ochi, Yasuko Tameno, Hitosuke Nishimura, Ichiro Minami, Kahori Inoue, Hirokazu Isono, Takahiro Saitoh, Masao Shimada, Taketoshi Hisa, Yasuo Okabe, Hidetoshi PLoS One Research Article RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval = 1.566–9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination. Public Library of Science 2010-12-22 /pmc/articles/PMC3008740/ /pubmed/21203526 http://dx.doi.org/10.1371/journal.pone.0015737 Text en Chano et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chano, Tokuhiro
Ikebuchi, Kaichiro
Tomita, Yasuhiko
Jin, Yufen
Inaji, Hideo
Ishitobi, Makoto
Teramoto, Koji
Ochi, Yasuko
Tameno, Hitosuke
Nishimura, Ichiro
Minami, Kahori
Inoue, Hirokazu
Isono, Takahiro
Saitoh, Masao
Shimada, Taketoshi
Hisa, Yasuo
Okabe, Hidetoshi
RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients
title RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients
title_full RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients
title_fullStr RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients
title_full_unstemmed RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients
title_short RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients
title_sort rb1cc1 together with rb1 and p53 predicts long-term survival in japanese breast cancer patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008740/
https://www.ncbi.nlm.nih.gov/pubmed/21203526
http://dx.doi.org/10.1371/journal.pone.0015737
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