How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

The Akt signalling pathway plays vital roles in controlling cellular responses to insulin as well as in proliferation and survival. Inhibition of Akt signalling leads to insulin resistance and type 2 diabetes, whereas hyperactivation of Akt promotes tumorigenesis. In this study, we investigate how m...

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Detalles Bibliográficos
Autores principales: Wullschleger, Stephan, Sakamoto, Kei, Johnstone, Lana, Duce, Suzanne, Fleming, Stewart, Alessi, Dario R.
Formato: Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008965/
https://www.ncbi.nlm.nih.gov/pubmed/20959631
http://dx.doi.org/10.1242/dmm.005603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008965/
https://www.ncbi.nlm.nih.gov/pubmed/20959631
http://dx.doi.org/10.1242/dmm.005603

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