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How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance
The Akt signalling pathway plays vital roles in controlling cellular responses to insulin as well as in proliferation and survival. Inhibition of Akt signalling leads to insulin resistance and type 2 diabetes, whereas hyperactivation of Akt promotes tumorigenesis. In this study, we investigate how m...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Limited
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008965/ https://www.ncbi.nlm.nih.gov/pubmed/20959631 http://dx.doi.org/10.1242/dmm.005603 |