1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone

The title compound, C(19)H(22)N(4)O(3)S, comprises a thienopyridine moiety which is characteristic for anti­platelet agents of the clopidogrel class of compounds. In the crystal, inversion dimers are formed through pairs of C—H⋯O inter­actions. The benzene ring plane and the nitro plane are almost c...

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Detalles Bibliográficos
Autores principales: Mu, Shuai, Yang, Miao, Liu, Deng-Ke, Liu, Chang-Xiao
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009028/
https://www.ncbi.nlm.nih.gov/pubmed/21588964
http://dx.doi.org/10.1107/S1600536810039085
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author Mu, Shuai
Yang, Miao
Liu, Deng-Ke
Liu, Chang-Xiao
author_facet Mu, Shuai
Yang, Miao
Liu, Deng-Ke
Liu, Chang-Xiao
author_sort Mu, Shuai
collection PubMed
description The title compound, C(19)H(22)N(4)O(3)S, comprises a thienopyridine moiety which is characteristic for anti­platelet agents of the clopidogrel class of compounds. In the crystal, inversion dimers are formed through pairs of C—H⋯O inter­actions. The benzene ring plane and the nitro plane are almost coplanar, with a dihedral angle of 0.83 (2)°. The piperazine ring adopts a chair conformation.
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spelling pubmed-30090282010-12-30 1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone Mu, Shuai Yang, Miao Liu, Deng-Ke Liu, Chang-Xiao Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(19)H(22)N(4)O(3)S, comprises a thienopyridine moiety which is characteristic for anti­platelet agents of the clopidogrel class of compounds. In the crystal, inversion dimers are formed through pairs of C—H⋯O inter­actions. The benzene ring plane and the nitro plane are almost coplanar, with a dihedral angle of 0.83 (2)°. The piperazine ring adopts a chair conformation. International Union of Crystallography 2010-10-09 /pmc/articles/PMC3009028/ /pubmed/21588964 http://dx.doi.org/10.1107/S1600536810039085 Text en © Mu et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Mu, Shuai
Yang, Miao
Liu, Deng-Ke
Liu, Chang-Xiao
1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone
title 1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone
title_full 1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone
title_fullStr 1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone
title_full_unstemmed 1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone
title_short 1-[4-(4-Nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone
title_sort 1-[4-(4-nitro­phen­yl)piperazin-1-yl]-2-(4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-5-yl)ethanone
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009028/
https://www.ncbi.nlm.nih.gov/pubmed/21588964
http://dx.doi.org/10.1107/S1600536810039085
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AT liudengke 144nitrophenylpiperazin1yl24567tetrahydrothieno32cpyridin5ylethanone
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