N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine

In the title compound, C(13)H(12)ClN(5), which is a derivative of the anti­tumor agent pazopanib {systematic name: 5-[[4-[(2,3-di­methyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide}, the indazole and pyrim­idine fragments form a dihedral angle of 62.63 (5)°. In the cr...

Descripción completa

Detalles Bibliográficos
Autores principales: Qi, Hao-Fei, Liu, Bing-Ni, Liu, Mo, Liu, Deng-Ke
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009102/
https://www.ncbi.nlm.nih.gov/pubmed/21589123
http://dx.doi.org/10.1107/S1600536810042753
_version_ 1782194606812692480
author Qi, Hao-Fei
Liu, Bing-Ni
Liu, Mo
Liu, Deng-Ke
author_facet Qi, Hao-Fei
Liu, Bing-Ni
Liu, Mo
Liu, Deng-Ke
author_sort Qi, Hao-Fei
collection PubMed
description In the title compound, C(13)H(12)ClN(5), which is a derivative of the anti­tumor agent pazopanib {systematic name: 5-[[4-[(2,3-di­methyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide}, the indazole and pyrim­idine fragments form a dihedral angle of 62.63 (5)°. In the crystal, pairs of mol­ecules related by twofold rotational symmetry are linked into dimers through π–π inter­actions between the indazole ring systems [centroid–centroid distance = 3.720 (2) Å]. Weak inter­molecular C—H⋯N hydrogen bonds further assemble these dimers into columns propagated in [001].
format Text
id pubmed-3009102
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-30091022010-12-30 N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine Qi, Hao-Fei Liu, Bing-Ni Liu, Mo Liu, Deng-Ke Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(13)H(12)ClN(5), which is a derivative of the anti­tumor agent pazopanib {systematic name: 5-[[4-[(2,3-di­methyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide}, the indazole and pyrim­idine fragments form a dihedral angle of 62.63 (5)°. In the crystal, pairs of mol­ecules related by twofold rotational symmetry are linked into dimers through π–π inter­actions between the indazole ring systems [centroid–centroid distance = 3.720 (2) Å]. Weak inter­molecular C—H⋯N hydrogen bonds further assemble these dimers into columns propagated in [001]. International Union of Crystallography 2010-10-30 /pmc/articles/PMC3009102/ /pubmed/21589123 http://dx.doi.org/10.1107/S1600536810042753 Text en © Qi et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Qi, Hao-Fei
Liu, Bing-Ni
Liu, Mo
Liu, Deng-Ke
N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine
title N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine
title_full N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine
title_fullStr N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine
title_full_unstemmed N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine
title_short N-(2-Chloro­pyrimidin-4-yl)-N,2-di­methyl-2H-indazol-6-amine
title_sort n-(2-chloro­pyrimidin-4-yl)-n,2-di­methyl-2h-indazol-6-amine
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009102/
https://www.ncbi.nlm.nih.gov/pubmed/21589123
http://dx.doi.org/10.1107/S1600536810042753
work_keys_str_mv AT qihaofei n2chloropyrimidin4yln2dimethyl2hindazol6amine
AT liubingni n2chloropyrimidin4yln2dimethyl2hindazol6amine
AT liumo n2chloropyrimidin4yln2dimethyl2hindazol6amine
AT liudengke n2chloropyrimidin4yln2dimethyl2hindazol6amine

Ejemplares similares