Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature

Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level...

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Autores principales: Goyal, Manu, Mohammad, Noorjahan, Palanki, Satya Dattatreya, Vaniawala, Salil N.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009444/
https://www.ncbi.nlm.nih.gov/pubmed/21206718
http://dx.doi.org/10.4103/0971-5851.73603
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author Goyal, Manu
Mohammad, Noorjahan
Palanki, Satya Dattatreya
Vaniawala, Salil N.
author_facet Goyal, Manu
Mohammad, Noorjahan
Palanki, Satya Dattatreya
Vaniawala, Salil N.
author_sort Goyal, Manu
collection PubMed
description Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date.
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spelling pubmed-30094442011-01-04 Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature Goyal, Manu Mohammad, Noorjahan Palanki, Satya Dattatreya Vaniawala, Salil N. Indian J Med Paediatr Oncol Case Report Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date. Medknow Publications 2010 /pmc/articles/PMC3009444/ /pubmed/21206718 http://dx.doi.org/10.4103/0971-5851.73603 Text en © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Goyal, Manu
Mohammad, Noorjahan
Palanki, Satya Dattatreya
Vaniawala, Salil N.
Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature
title Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature
title_full Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature
title_fullStr Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature
title_full_unstemmed Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature
title_short Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? – A case report with review of literature
title_sort primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: how successfully treated? – a case report with review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009444/
https://www.ncbi.nlm.nih.gov/pubmed/21206718
http://dx.doi.org/10.4103/0971-5851.73603
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