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The p53-Target Gene Puma Drives Neutrophil-Mediated Protection against Lethal Bacterial Sepsis

Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response to bacterial sepsis. Puma(−/−) mice rapidly died when challenged with bacteria...

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Detalles Bibliográficos
Autores principales:	Garrison, Sean P., Thornton, Justin A., Häcker, Hans, Webby, Richard, Rehg, Jerold E., Parganas, Evan, Zambetti, Gerard P., Tuomanen, Elaine I.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009602/ https://www.ncbi.nlm.nih.gov/pubmed/21203486 http://dx.doi.org/10.1371/journal.ppat.1001240

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