Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin

BACKGROUND: We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells in a concentration-dependent manner. METHODS: To investigate the effect of PHI,...

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Detalles Bibliográficos
Autores principales: Jiang, Shaohong, Ma, Xudong, Huang, Yiqun, Xu, Yunlu, Zheng, Ruiji, Chiao, Jen-Wei
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009608/
https://www.ncbi.nlm.nih.gov/pubmed/21114827
http://dx.doi.org/10.1186/1756-8722-3-48

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