Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation

Over half of all proteins are glycosylated, and alterations in glycosylation have been observed in numerous physiological and pathological processes. Attached glycans significantly affect protein function; but, contrary to polypeptides, they are not directly encoded by genes, and the complex process...

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Detalles Bibliográficos
Autores principales: Lauc, Gordan, Essafi, Abdelkader, Huffman, Jennifer E., Hayward, Caroline, Knežević, Ana, Kattla, Jayesh J., Polašek, Ozren, Gornik, Olga, Vitart, Veronique, Abrahams, Jodie L., Pučić, Maja, Novokmet, Mislav, Redžić, Irma, Campbell, Susan, Wild, Sarah H., Borovečki, Fran, Wang, Wei, Kolčić, Ivana, Zgaga, Lina, Gyllensten, Ulf, Wilson, James F., Wright, Alan F., Hastie, Nicholas D., Campbell, Harry, Rudd, Pauline M., Rudan, Igor
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009678/
https://www.ncbi.nlm.nih.gov/pubmed/21203500
http://dx.doi.org/10.1371/journal.pgen.1001256

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